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Home > Natural Products > Alkaloids (Find 491 items)

Alkaloids

(+)-Corytuberine

(517-56-6)
Semi-synthetic aristolactams-inhibitor of CDK2 enzyme

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Pseurotin A

(58523-30-1)
Pseurotin A is a fungal metabolite with an unusual hetero-spirocyclic ring system. It has potent neuritogenic activity in PC12 phaechromocytoma cells, a useful model for adrenergic neuronal differentiation. Pseurotin A induces multipolar and branching neurites comparable to β-NGF, an endogenous neurotrophic factor. Pseurotin A also exhibits chitinase inhibition and acts synergistically with azole antifungal agents.

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enniatin B1

(19914-20-6)
Enniatins are cyclohexadepsipeptides commonly isolated from fungi and are known to have antibiotic properties. Many act as ionophores, forming pores in cellular membranes to allow selective ion transport.Enniatin B1 is one of four major analogs of the enniatin complex . It has been shown to induce apoptosis in several cancer lines (EC50s ≤ 10 μM) and to decrease the activation of the cell proliferation kinase, ERK (p44/p42). Enniatin B1 also inhibits the multi-drug resistance transporter Pdr5p f

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Veratridine

(71-62-5)
Veratridine (3-Veratroylveracevine), a alkaloid derived from plants in the family Liliaceae, is a sodium channel agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM.

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Alkaloids exist in nature (mainly plants, but some also exist in animals), a type of nitrogen-containing basic organic compounds, which have alkaloid-like properties. According to the basic structure of alkaloids, it can be divided into about 60 categories. Main types: organic amines, pyrrolidines, pyridines, isoquinolines, indoles, scopolamines, imidazoles, quinazolones, purines, steroids, diterpenes, and others.
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