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Home > Natural Products > Alkaloids (Find 491 items)

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Elementary Substance

Sort Alkaloids Alphabetically

Alkaloids

Koumine

(1358-76-5)
Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells[1]. Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities[3], protects against the development of arthritis in Rheumatoid arthritis (RA) animal models[2].

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Corynoxine

(6877-32-3)
Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.IC50 value:Tareget: Autophagy inducerIn vivo, Cory promotes the formation of autophagosomes in the fat bodies of Drosophila. By inducing autophagy, Cory promotes the clearance of wild-type and A53T α-syn in inducible PC12 cells. Interestingly, different from its enantiomer Cory B, Cory induces autophagy through the Akt/mTOR pathway as evidenced by the reduction

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Mimosine

(500-44-7)
light tan to pink crystalline powder

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Seneciphylline

(480-81-9)
Seneciphylline is a toxic pyrrolizidine alkaloid in Senecio plants[1]. Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities[2].

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ALPHA-AMANITIN

(23109-05-9)
alpha-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.

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Canadine

(5096-57-1)
(S)-(-)-Canadine is a protoberberine alkaloidwhich potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling. (S)-(-)-Canadine has a strong central nervous system-depressing activity and is used in the preparation of tetrahydroprotoberberine derivatives as new antipsychotic agents.

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(-)-Cytochalasin D

(22144-77-0)
A cell cycle arresting compound used in actin polymerization studies and cytological research

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Lobeline sulfate

(134-64-5)
Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) is a nonstimulant medication that can alter dopamine uptake in brain. Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) inhibits nicotine-induced hyperactivity and is effective in smoking cessation[1][2].

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Coclaurine

(486-39-5)
Coclaurine is a class of tetrahydroisoquinoline alkaloids isolated from Sarcopetalum harveyanum. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist[1][2].

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Asperin

(50773-42-7)

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Alkaloids exist in nature (mainly plants, but some also exist in animals), a type of nitrogen-containing basic organic compounds, which have alkaloid-like properties. According to the basic structure of alkaloids, it can be divided into about 60 categories. Main types: organic amines, pyrrolidines, pyridines, isoquinolines, indoles, scopolamines, imidazoles, quinazolones, purines, steroids, diterpenes, and others.

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