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Home > Active Pharmaceutical Ingredients > Antineoplastic Agents (Find 287 items)

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Antineoplastic Agents

Sort Antineoplastic Agents Alphabetically

Antineoplastic Agents

Antineoplastic agents combat tumors through distinct mechanisms. Alkylating antineoplastic agents form DNA crosslinks, blocking replication. Antimetabolite antineoplastic agents mimic metabolites to disrupt DNA/RNA synthesis. Both classes target rapidly dividing cells but differ in molecular interactions. Read more about Antineoplastic Agents including data on CAS Numbers, properties, materials, and products from the suppliers listed on ECHEMI.

Docetaxel

(125354-16-7)
Docetaxal is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin.

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Irinotecan

(97682-44-5)
Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively Anti-tumor drugs. It is a DNA synthesis inhibitor. It is a semi-synthetic derivative of camptothecin; used to prepare irinotecan hydrochloride and irinotecan hydrochloride trihydrate; an anticancer drug.

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Erlotinib

(183321-74-6)
A tyrosine kinase inhibitor

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Fludarabine

(21679-14-1)
DNA synthesis and methylation inhibitor;A cell permeable agent that interferes with DNA synthesis and repair; also inhibits RNA transcription Its phosphate group is quickly cleaved in the blood, and the remaining 2-fluoroarabinosine (Fara-A) enters the cell and is phosphorylated into the active metabolite Farar-ATP to play a role. For chronic lymphocytic leukemia.

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Cisplatin

(15663-27-1)
1. Muscle relaxant (skeletal)
2. Antitumor agent
3. Used as an antineoplastic

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Gemcitabine hydrochloride

(122111-03-9)
An antineoplastic. Suitable for the treatment of inoperable advanced or metastatic pancreatic cancer and the treatment of locally advanced or metastatic non-small cell lung cancer, the treatment of intermediate and advanced non-small cell lung cancer, non-small cell lung cancer, pancreatic cancer, bladder cancer, breast cancer and Other solid tumors.

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Dasatinib

(302962-49-8)
Suitable for treatment of chronic myeloid leukemia which is resistant or intolerant to the treating programs including imatinib mesylate. A new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. Antineoplastic Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of ＜1 nM, 0.8 nM and 79 nM, respectively. Directly targets wild-type and mutant c-Abl kinase domains

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Oxaliplatin

(61825-94-3)
A antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA Used to treat colorectal cancer. Anti-tumor drugs for the treatment of rectal cancer

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Doxorubicin

(23214-92-8)
Doxorubicin (adriamycin) is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces species, first reported in 1967 and later approved for human therapeutic use as an antitumour agent for the treatment of a wide range of cancers. Doxorubicin also exhibits anti-HIV and antibacterial activity. The mode of action of doxorubicin is thought to be due to intercalation of DNA and inhibition of nucleic acid synthesis.

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Hydroxycamptothecin

(19685-09-7)
A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy

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Antineoplastic agents are a class of drugs used to treat tumor diseases. In short, there are chemotherapy drugs and biological agents. At present, there are more than 80 kinds of antineoplastic agents common in the world, which can be roughly divided into the following 6 categories: cytotoxic drugs, hormone drugs, biological response modifiers, monoclonal antibody drugs, other drugs, auxiliary drugs and so on. The "ECHEMI Antineoplastic Agents" list mainly supplies APIs for such drugs.

More Information

Antineoplastic agents are a large group of compounds having different structures but with one common antineoplastic property, namely, to inhibit the proliferation of malignant cells. Through other mechanisms, these agents disrupt DNA replication, inhibiting the cell's metabolism, or inhibiting the essential enzymatic process of the cell. For example, alkylating agents, including bendamustine and dacarbazine, introduce alkyl groups to DNA which causes breakage of the strand and death of the alkylated cell.

Fludarabine phosphate and azathioprine are antimetabolites that mimic the natural substrates and thereby block the synthesis of nucleic acid and inhibit the growth of tumours. These agents have proved efficacious in a variety of malignancies and thus are key components to chemotherapy regimens.

Applications of antineoplastic agents include:

● Treatment of hematologic cancers such as leukemia and lymphoma.

● It is used in the management of solid tumours such as breast, lung and colorectal cancers.

● Conditioning before hematopoietic stem cell transplantation.

● Preventive maintenance therapy for cancer recurrence.

● It’s in combination with other therapeutic modalities, such as radiation and immunotherapy, for the sake of enhancing treatment efficacy.

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