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Antineoplastic Agents

Antineoplastic agents combat tumors through distinct mechanisms. Alkylating antineoplastic agents form DNA crosslinks, blocking replication. Antimetabolite antineoplastic agents mimic metabolites to disrupt DNA/RNA synthesis. Both classes target rapidly dividing cells but differ in molecular interactions. Read more about Antineoplastic Agents including data on CAS Numbers, properties, materials, and products from the suppliers listed on ECHEMI.

Idoxifene

(116057-75-1)
SERM for treatment of urogenital atrophy weak estrogen and antiestrogen in uterus

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Peplomycin

(68247-85-8)
Antitumor antibiotics. It is clinically used for the treatment of squamous cell carcinoma, such as head squamous cell carcinoma, tongue cancer, mouth floor cancer, buccal mucosa cancer, skin squamous cell carcinoma, and malignant lymphoma. It also has a certain effect on lung cancer, prostate cancer, and malignant melanoma.

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iMatinib related substance C

(938082-57-6)
Imatinib (Piperidine)-1-oxide is an impurity of Imatinib (Gleevec) (G407000). Imatinib impurity C.

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Antineoplastic agents are a class of drugs used to treat tumor diseases. In short, there are chemotherapy drugs and biological agents. At present, there are more than 80 kinds of antineoplastic agents common in the world, which can be roughly divided into the following 6 categories: cytotoxic drugs, hormone drugs, biological response modifiers, monoclonal antibody drugs, other drugs, auxiliary drugs and so on. The "ECHEMI Antineoplastic Agents" list mainly supplies APIs for such drugs.

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Antineoplastic agents are a large group of compounds having different structures but with one common antineoplastic property, namely, to inhibit the proliferation of malignant cells. Through other mechanisms, these agents disrupt DNA replication, inhibiting the cell's metabolism, or inhibiting the essential enzymatic process of the cell. For example, alkylating agents, including bendamustine and dacarbazine, introduce alkyl groups to DNA which causes breakage of the strand and death of the alkylated cell.

Fludarabine phosphate and azathioprine are antimetabolites that mimic the natural substrates and thereby block the synthesis of nucleic acid and inhibit the growth of tumours. These agents have proved efficacious in a variety of malignancies and thus are key components to chemotherapy regimens.

Applications of antineoplastic agents include:

● Treatment of hematologic cancers such as leukemia and lymphoma.

● It is used in the management of solid tumours such as breast, lung and colorectal cancers.

● Conditioning before hematopoietic stem cell transplantation.

● Preventive maintenance therapy for cancer recurrence.

● It’s in combination with other therapeutic modalities, such as radiation and immunotherapy, for the sake of enhancing treatment efficacy.

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