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Home > Active Pharmaceutical Ingredients > Antineoplastic Agents (Find 287 items)

Antineoplastic Agents

Antineoplastic agents combat tumors through distinct mechanisms. Alkylating antineoplastic agents form DNA crosslinks, blocking replication. Antimetabolite antineoplastic agents mimic metabolites to disrupt DNA/RNA synthesis. Both classes target rapidly dividing cells but differ in molecular interactions. Read more about Antineoplastic Agents including data on CAS Numbers, properties, materials, and products from the suppliers listed on ECHEMI.

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Vinblastine sulfate

(143-67-9)
Labelled Vinblastine (V314000). Antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. An antineoplastic.

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Sunitinib malate

(341031-54-7)
A multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK). Antineoplastic.

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Dacarbazine

(4342-03-4)
Dacarbazine is used as an antineoplastic for treatment of malignant melanoma and sarcomas.

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Axitinib

(319460-85-0)
Axitinib is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

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Clofarabine

(123318-82-1)
ISecond generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic

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Floxuridine

(50-91-9)
renal function diagnosis

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Topotecan hydrochloride

(119413-54-6)
A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.

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Flutamide

(13311-84-7)
Antiandrogen; antineoplastic (hormonal).

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Lapatinib ditosylate

(388082-77-7)
Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.

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Antineoplastic agents are a class of drugs used to treat tumor diseases. In short, there are chemotherapy drugs and biological agents. At present, there are more than 80 kinds of antineoplastic agents common in the world, which can be roughly divided into the following 6 categories: cytotoxic drugs, hormone drugs, biological response modifiers, monoclonal antibody drugs, other drugs, auxiliary drugs and so on. The "ECHEMI Antineoplastic Agents" list mainly supplies APIs for such drugs.

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Antineoplastic agents are a large group of compounds having different structures but with one common antineoplastic property, namely, to inhibit the proliferation of malignant cells. Through other mechanisms, these agents disrupt DNA replication, inhibiting the cell's metabolism, or inhibiting the essential enzymatic process of the cell. For example, alkylating agents, including bendamustine and dacarbazine, introduce alkyl groups to DNA which causes breakage of the strand and death of the alkylated cell.

Fludarabine phosphate and azathioprine are antimetabolites that mimic the natural substrates and thereby block the synthesis of nucleic acid and inhibit the growth of tumours. These agents have proved efficacious in a variety of malignancies and thus are key components to chemotherapy regimens.

Applications of antineoplastic agents include:

● Treatment of hematologic cancers such as leukemia and lymphoma.

● It is used in the management of solid tumours such as breast, lung and colorectal cancers.

● Conditioning before hematopoietic stem cell transplantation.

● Preventive maintenance therapy for cancer recurrence.

● It’s in combination with other therapeutic modalities, such as radiation and immunotherapy, for the sake of enhancing treatment efficacy.

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