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Home > Active Pharmaceutical Ingredients > Antineoplastic Agents (Find 287 items)

Antineoplastic Agents

Antineoplastic agents combat tumors through distinct mechanisms. Alkylating antineoplastic agents form DNA crosslinks, blocking replication. Antimetabolite antineoplastic agents mimic metabolites to disrupt DNA/RNA synthesis. Both classes target rapidly dividing cells but differ in molecular interactions. Read more about Antineoplastic Agents including data on CAS Numbers, properties, materials, and products from the suppliers listed on ECHEMI.

Mitomycin C

(50-07-7)
Mitomycin C is the most studied of a family of highly distinctive blue/purple metabolites produced by several Streptomyces species. Mitomyin C exhibits potent antibacterial and antitumour activity and inhibits DNA synthesis by intercalation, blocking nuclear division with the induction of apoptosis in cancer cells.

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Tegafur

(17902-23-7)
Used as an antineoplastic

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Bleomycin sulfate

(9041-93-4)
Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.

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Pirfenidone

(53179-13-8)
2(1H)-Pyridinone,5-methyl-1-phenyl- (CAS NO.53179-13-8) is used in multiple fibrotic conditions, including those of the lung, kidney and liver.

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Lomustine

(13010-47-4)
Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, chlorozotocin, nimustine, ranimustine. Antineoplastic.

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Nitrogen mustard

(55-86-7)
It has been used as an antineoplastic. A nitrogen mustard prepared by action of thionyl chloride on 2,2’(methylimino)-diethanol in trichloroethylene.

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Idarubicin

(58957-92-9)
Inhibit tumor growth and fight breast cancer.

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Raltitrexed

(112887-68-0)
Folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives. Antineoplastic

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Antineoplastic agents are a class of drugs used to treat tumor diseases. In short, there are chemotherapy drugs and biological agents. At present, there are more than 80 kinds of antineoplastic agents common in the world, which can be roughly divided into the following 6 categories: cytotoxic drugs, hormone drugs, biological response modifiers, monoclonal antibody drugs, other drugs, auxiliary drugs and so on. The "ECHEMI Antineoplastic Agents" list mainly supplies APIs for such drugs.

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Antineoplastic agents are a large group of compounds having different structures but with one common antineoplastic property, namely, to inhibit the proliferation of malignant cells. Through other mechanisms, these agents disrupt DNA replication, inhibiting the cell's metabolism, or inhibiting the essential enzymatic process of the cell. For example, alkylating agents, including bendamustine and dacarbazine, introduce alkyl groups to DNA which causes breakage of the strand and death of the alkylated cell.

Fludarabine phosphate and azathioprine are antimetabolites that mimic the natural substrates and thereby block the synthesis of nucleic acid and inhibit the growth of tumours. These agents have proved efficacious in a variety of malignancies and thus are key components to chemotherapy regimens.

Applications of antineoplastic agents include:

● Treatment of hematologic cancers such as leukemia and lymphoma.

● It is used in the management of solid tumours such as breast, lung and colorectal cancers.

● Conditioning before hematopoietic stem cell transplantation.

● Preventive maintenance therapy for cancer recurrence.

● It’s in combination with other therapeutic modalities, such as radiation and immunotherapy, for the sake of enhancing treatment efficacy.

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