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Home > Active Pharmaceutical Ingredients > Circulatory System Drugs (Find 29 items)

Circulatory System Drugs

Ciprofibrate

(52214-84-3)
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport. Ciprofibrate activates PPARα with an EC50 value of 20 μM and only marginally affects PPARγ (EC50 = >300 μM). It has been shown to lower adipose tissue weight and reduce plasma insulin concentrations in obese rat

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Cinepazide

(23887-46-9)
Cinepazide is a vasodilator.Target: OthersCinepazide is a vasodilator. Cinepazide (30 mg/kg, i.v.) potentiated the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP, Intravertebral cinepazide(1-10 mg) increased vertebral blood flow in a dose-related manner and the effect was partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. Cinepazide resembled cinnarizine and papaverine in that the drug

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Cholestyramine

(11041-12-6)
Lipid-lowering drugs for type Ⅱ hyperlipidemia, atherosclerosis and other diseases. Antihyperlipidemic; ion-exchange resin (bile salts).Cholestyramine resin is the drug of choice for type IIa hyperlipoproteinemia.When used in conjunction with a controlleddiet, it reduces -lipoproteins. The drug is an insolublepolymer and, thus, probably one of the safest because itis not absorbed from the gastrointestinal tract to cause systemictoxic effects.

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Cinepazide maleate

(26328-04-1)
Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.

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Conivaptan hydrochloride

(168626-94-6)
Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist).

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Cyclovirobuxine

(860-79-7)
Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR[1]. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis[2]. Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction[3].

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Cilazapril

(88768-40-5)
An ACE inhibitor.Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive

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Clinofibrate

(30299-08-2)
An antilipemic, used as an anti-atherosclerosis agent

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Circulatory system drugs are about drugs that have the function of regulating the human circulatory system. The circulatory system is a system of body fluids (including blood, lymph and tissue fluids) and pipes through which circulation flows. Circulatory system drugs mainly include cardiovascular system drugs and diuretics. "Circulatory System Drugs" on ECHEMI covers lipid regulating drugs, angina pectoris drugs, calcium channel blockers, anti-congestive heart failure drugs, antihypertensive drugs, antiarrhythmics drugs, anti shock vasoactive drugs, ace inhibitor, peripheral vasodilators, heart failure treatments and drugs, Anti-atherosclerotic drugs, β-adrenergic receptor blockers and other circulatory system drugs, mainly supply raw materials for such drugs.
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