Product
Supplier
Encyclopedia
Inquiry
Home > Pharmaceutical Intermediates > CNS Agents (Find 1 items)

CNS Agents

2-[[4-[1-Methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]quinoline

(898562-94-2)
PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE. IC50 value: 0.37 nM [1]Target: PDE10APDE10A subcutaneously administrated at dose of 1 mg/kg elevates striatal cGMP about 3 fold in male CD-1 mice, while PDE10A subcutaneously administrated at dose of 3.2 mg/kg displays a maximal elevation of striatal cGMP approximately a 5-fold increase in male CD-1 mice. PDE10A intravenous injected at a dose of 0.1 mg/kg in Sprague-Dawle

Product List

Request for quotation , get quotes from more suppliers.

CNS Agents Intermediates are some key chemical raw materials or products in the synthesis process of central nervous system agents. You can easily find high-quality new intermediates, products and their manufacturers or suppliers on ECHEMI. We will always track the research and development of new products on central nervous system.
Complaint
Email:
Message:
Send Message