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Coumarin and Coumarine Derivatives
Coumarin and Derivatives
Wedelolactone
(524-12-9)
Wedelolactone, a natural product from Ecliptae herba, suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex[1]. Wedelolactone inhibits 5-lipoxygenase (5-Lox) (IC50~2.5 μM) activity by an oxygen radical scavenging mechanism. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt[2]. Anti-cancer, anti-inflammatory, and antioxidant activities[3].
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Industrial Grade / 99%
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Coumarin, found naturally in black cougar, whiff chrysanthemum, wild viburnum, and orchid, has fresh hay and coumarin flavors, and is generally not eaten, and is allowed for tobacco and external use. Mainly divided into: simple, furan, pyran, double coumarin, isocoumarin and other coumarin.