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Home > Natural Products > Coumarin and Derivatives (Find 121 items)

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Elementary Substance

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Coumarin and Derivatives

Scopoletin

(92-61-5)
The aglucone of Scopolin. Used for cosmetics, topical formulations, and foods. Dyes can be used to detect the release of reactive oxygen species during oxidative bursts; peroxygen scavengers; acetylcholinesterase inhibitors. Clinically, it has the effects of expelling wind, anti-inflammatory, analgesic and expectorant.

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(-)-Praeruptorin A

(14017-71-1)

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Psoralidin

(18642-23-4)
ChEBI: A member of the class of coumestans that is coumestan substituted by hydroxy groups at positions 3 and 9 and a prenyl group at position 2 respectively.

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Coumestrol

(479-13-0)
This compound has estrogenic activity.It exhibits bright blue fluorescence in neutral or acid solution, and greenish-yellow fluorescence in strong alkali solution

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(+)-Byakangelicin

(482-25-7)
Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects[1]. Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of drug-drug interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones[2].

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Wedelolactone

(524-12-9)
Wedelolactone, a natural product from Ecliptae herba, suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex[1]. Wedelolactone inhibits 5-lipoxygenase (5-Lox) (IC50~2.5 μM) activity by an oxygen radical scavenging mechanism. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt[2]. Anti-cancer, anti-inflammatory, and antioxidant activities[3].

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Scopolin

(531-44-2)
Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots[1]. Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades[2].

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Bergaptol

(486-60-2)
A hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 and 42.93 μM, respectively. Recent studies suggest that it may have antiproliferative and anticancer properties.

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Fraxinol

(486-28-2)
Ash tree essence has anti-bacterial, antiseptic and active ammonia scavenging effects.

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Daphnoretin

(2034-69-7)
Daphnoretin (Dephnoretin), isolated from Wikstroemia indica, possesses antiviral activity[1]. Daphnoretin likes PMA, may direct activation of protein kinase C which in turn activated NADPH oxidase and elicited respiratory burst[2].

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Coumarin, found naturally in black cougar, whiff chrysanthemum, wild viburnum, and orchid, has fresh hay and coumarin flavors, and is generally not eaten, and is allowed for tobacco and external use. Mainly divided into: simple, furan, pyran, double coumarin, isocoumarin and other coumarin.

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Perfuming Antiparasitic Drugs Nucleic Acid Drugs Inhibitors Amphoteric Surfactants Water Retention Agent Respiratory Tract Gel Forming Flocculant Hair Waving or Straightening

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