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Home > Biochemical Engineering > Inflammation Mediators (Find 128 items)

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Elementary Substance

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Inflammation Mediators

18,18,20-trimethylprostaglandinE2

(80003-51-6)

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PGD3

(71902-47-1)
Prostaglandin D3 (PGD3) is produced by the metabolism of EPA via the COX pathway. It is equipotent to PGD2 in decreasing systemic blood pressure in rats and in decreasing intraocular pressure in rabbits. However, it is 3-5 times more potent than PGD2 in the inhibition of ADP-induced human platelet aggregation.[Cayman Chemical]

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Cicaprost

(94079-80-8)
A highly potent anti-metastatic Prostacyclin (P839060) analogue.

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11-deoxy-15-keto-13,14-dihydro-11 beta,16-cycloprostaglandin E2

(74158-09-1)
Bicyclo prostaglandin E2 (bicyclo PGE2) is a stable breakdown product of PGE2 and 13,14-dihydro-15-keto PGE2 . Bicyclo PGE2 is a stable, base-catalyzed transformation product of 13,14-dihydro-15-keto PGE2. 13,14-dihydro-15-keto PGE2 itself is a metabolite of PGE2 found in human plasma at a median level of 20-25 pg/ml. Due to the inherent instability of 13,14-dihydro-15-keto PGE2, it is advisable to quantify it as bicyclo PGE2 to estimate PGE2 biosynthesis or metabolism in vivo.

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ethyl dihomo-gamma-linolenate

(55968-21-3)
Dihomo-γ-linolenic acid (DGLA) is a metabolite produced by chain elongation of the essential fatty acid γ-linolenic acid. Ethyl DGLA is an esterified version of the free acid which is less water soluble, but more amenable for the formulation of DGLA-containing diets and dietary supplements. DGLA has been advanced as a possible treatment for various inflammatory disorders. Evening primrose oil is a DGLA-rich nutraceutical which has been advocated for such uses.[Cayman Chemical]

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3-(2,5,8-Tetradecatrien-1-yl)-2-oxiranebutanoic acid

(81246-84-6)

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13,14-Dihydro-15-keto-PGE1

(5094-14-4)

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15-hydroxyeicosatrienoicacid

(82451-61-4)

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2,3-Dinor-8-isoPGF2α

(221664-05-7)

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Dihydro-PGE1

(19313-28-1)

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Inflammatory mediators refer to chemically active substances that are produced and released by local tissues or plasma under the action of inflammatory factors, and participate in or cause inflammatory reactions, so they are also called chemical mediators. There are two types, exogenous (bacteria and their products) and endogenous, but mainly the latter. Endogenous can be divided into two categories: cell-derived and plasma-derived. "Cell-derived" include vasoactive amines, prostaglandins, leukotrienes, lysosomal components and lymphokines, etc. The inflammatory mediators produced by plasma include kinin system, complement system, coagulation system and fibrinolytic system.

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