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Inhibitors

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

(79183-19-0)

Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE SDS

Creative Enzymes
Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
Dayang Chem (Hangzhou) Co.,Ltd
LEAP CHEM CO., LTD.

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1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine

(343787-29-1)

CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM.

1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine SDS

Creative Enzymes
Industrial Grade / 99.00%

Shaanxi Dideu Medichem Co. Ltd
Dayang Chem (Hangzhou) Co.,Ltd
LEAP CHEM CO., LTD.

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12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole

(136194-77-9)

Potent protein kinase C (PKC) inhibitor (IC 50 = 7.9 nM). In vitro, discriminates between Ca 2+ -dependent and -independent isoforms of PKC; selectively inhibits PKC α and PKC β 1 (IC 50 values are 2.3 and 6.2 nM respectively) but does not inhibit the activity of PKC δ , - ε , or - ζ (IC 50 > 3 μ M). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC 50 values are 5, 30, 130 and 370 nM respectively).

12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole SDS

- / 99.00%

LEAP CHEM CO., LTD.
Industrial Grade / 99%

henan kanbei chemical co.,ltd
Industrial Grade / 99.0%

Shaanxi Dideu Medichem Co. Ltd
Dayang Chem (Hangzhou) Co.,Ltd

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1-AZAKENPAULLONE

(676596-65-9)

A selective inhibitor of glycogen synthase kinase-3β.

1-AZAKENPAULLONE SDS

Industrial Grade / 99%

henan kanbei chemical co.,ltd
Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
Dayang Chem (Hangzhou) Co.,Ltd
LEAP CHEM CO., LTD.

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1,1′-[2-(Phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone]

(1415800-43-9)

UNC 1215 is ; a potent, selective antagonist of L3MBTL3 with cellular activity. UNC1215 binds the MBT domains of L3MBTL3 with a Kd of 120 nM, competitively displacing mono- or dimethyl-lysine containing peptides

1,1′-[2-(Phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone] SDS

Pharmacy Grade / 99%

Changzhou Xuanming Pharmaceutical Techno
Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
HANGZHOU JHECHEM CO LTD
ATK CHEMICAL COMPANY LIMITED

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1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine

(172889-26-8)

A highly potent and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase

1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine SDS

- / 98%

Creative Enzymes
Dayang Chem (Hangzhou) Co.,Ltd
LEAP CHEM CO., LTD.
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD

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1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(1092788-83-4)

PP-121 is a multi-target inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, respectively, and also inhibits DNA-PK with IC50 of 60 nM.

1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine SDS

- / 99%

Creative Enzymes
Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
LEAP CHEM CO., LTD.
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD

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1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]piperazine

(1227158-85-1)

This Hif1a inhibitor (FW = 525.53 g/mol; CAS 1227158-85-1; Solubility: <1 mg/mL DMSO or H2O) targets the transcription factor hypoxia-inducible factor-1 (HIF-1), which plays an essential role in tumor development, tumor progression, and resistance to chemo- and radiotherapy. BAY 87-2243 inhibits HIF-1α and HIF-2α accumulation under hypoxic conditions in the H460 Non-Small Cell Lung Cancer (NSCLC) cell line but is without effect on HIF-1α protein levels that are induced by such hypoxia mim

1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]piperazine SDS

Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
Dayang Chem (Hangzhou) Co.,Ltd
LEAP CHEM CO., LTD.
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD

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1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione

(112648-68-7)

Phospholipase C inhibitor. Inhibits agonist-induced platelet aggregation with IC 50 values of 1-5 μ M. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces (IC 50 < 50 nM) and exhibits antinociceptive activity in vivo .

1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione SDS

Industrial Grade / 99.0%

Shaanxi Dideu Medichem Co. Ltd
HANGZHOU JHECHEM CO LTD
Food Grade / 99%

$10/KG EXW

hua yang chem
HANGZHOU TIANYE CHEMICALS CO., LTD

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1-Cyclopentyl-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-1H-indazole-4-carboxamide

(1396772-26-1)

EPZ005687 is a potent, selective inhibitor of the lysine methyltranferase EZH2 (Ki = 24 nM), the enzymatic subunit of polycomb repressive complex 2 (PRC2). It acts competitively with the EZH2 substrate S-adenosylmethionine. EPZ005687 has greater than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against EZH1. It blocks trimethylation of the PRC2 target histone 3 lysine 27 (IC50 = 80 nM), decreasing the proliferation of lymphoma cells carrying mutant

1-Cyclopentyl-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-1H-indazole-4-carboxamide SDS

- / 98%

Creative Enzymes
ATK CHEMICAL COMPANY LIMITED
Chongqing Chemdad
- / 98%

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd.

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Small molecule inhibitors are a type of molecules that can interact with proteins and reduce the biological activity of target proteins, including enzyme inhibitors, transcription factor inhibitors, and ion channel blockers. It acts on popular signaling pathways, popular targets and popular research fields: MAPK, PI3K, JAK / STAT and other signaling pathways, HDAC, Aurora kinase, CDK and cell cycle regulators, integrase / protease, etc. Research fields such as epigenetics, CNS, GPCR, anti-virus, antibacterial / anti-inflammatory. It is an effective tool for cell biology research.

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Inhibitors

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

1-{2-[5-(2-Methoxy-ethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine

12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole

1-AZAKENPAULLONE

1,1′-[2-(Phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone]

1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine

1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]piperazine

1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione

1-Cyclopentyl-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-1H-indazole-4-carboxamide

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