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Inhibitors

5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol

A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838

5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol SDS

- / 99%

Creative Enzymes
LEAP CHEM CO., LTD.
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD
Conier Chem&Pharma Limited

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5,6-Dimethylxanthenone-4-acetic acid

(117570-53-3)

Vadimezan is a drug that displayed vascular-disrupting activity and induced haemorrhagic necrosis and tumour regression in pre-clinical animal models.

5,6-Dimethylxanthenone-4-acetic acid SDS

- / 99.00%

LEAP CHEM CO., LTD.
Different Grade / 99.9%

$0.1/KG EXW

Amitychem
- / 99%

Creative Enzymes
Industrial Grade / 99.0%

Shaanxi Dideu Medichem Co. Ltd

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5-Hydroxymethyltolterodine

(207679-81-0)

A metabolite of Tolterodine, a muscarinic receptor antagonist used in the treatment of urinary incontinence.

5-Hydroxymethyltolterodine SDS

- / 99.00%

LEAP CHEM CO., LTD.
Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
Dayang Chem (Hangzhou) Co.,Ltd
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD

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5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine

(761439-42-3)

Human anaplastic lymphoma kinase (ALK) is an oncogene that is amplified in neuroblastomas and when juxtaposed with various fusion partners, its constitutive kinase activity is associated with the development of a type of anaplastic large cell lymphoma (ALCL). TAE684 is an ALK inhibitor that blocks the proliferation of ALCL-derived and ALK-dependent cell lines with IC50 values of 2-5 nM. When tested against a panel of 35 cells transformed by various tyrosine kinases, TAE684 demonstrated 100- to 1

5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine SDS

- / 99%

Creative Enzymes
Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
LEAP CHEM CO., LTD.
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD

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5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one

(209410-46-8)

VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome.

5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one SDS

Industrial Grade / 99%

henan kanbei chemical co.,ltd
- / 99%

Creative Enzymes
Industrial Grade, Feed Grade, Food Grade, Pharma Grade / 99%

$11.11/KG EXW

Shaanxi Dideu Medichem Co. Ltd
LEAP CHEM CO., LTD.

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5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

(648450-29-7)

AS-605240 is a specific and orally active inhibitor of the PI3Kγ, with an IC50 of 8 nM, and a Ki of 7.8 nM.

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione SDS

Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
LEAP CHEM CO., LTD.
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD
HANGZHOU JHECHEM CO LTD

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5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5-dimethoxyphenylamide

(944261-79-4)

A selective NaV1.8 sodium channel blocker, reduces behavioral measures of chronic pain.

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5-dimethoxyphenylamide SDS

Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD
LEAP CHEM CO., LTD.
Conier Chem&Pharma Limited

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5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine

(935666-88-9)

AZD-1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of < 0.4 nM, selectively against JAK3 and Tyk2, and to a smaller extent against JAK1.

5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine SDS

- / 99.00%

LEAP CHEM CO., LTD.
Shaanxi Kaierkai Pharmaceutical Technolo
Industrial Grade / 99%

henan kanbei chemical co.,ltd
- / 99%

Creative Enzymes

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5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE

(4311-88-0)

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.

5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE SDS

- / 97%

Creative Enzymes
Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
LEAP CHEM CO., LTD.
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD

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5-Carboxy-8-hydroxyquinoline

(5852-78-8)

8-Hydroxyquinoline-5-carboxylic Acid is an inhibitor of KDM2/7 histone demethylase. 8-Hydroxyquinoline-5-carboxylic acid has also shown potential to be used as a regulator of plant growth.

5-Carboxy-8-hydroxyquinoline SDS

- / 99.00%

LEAP CHEM CO., LTD.
Pharmacy Grade / 99%

Greenbo Biochem
Industrial Grade / 99%

henan kanbei chemical co.,ltd
Pharmacy Grade / 99%

LEADER BIOCHEMICAL GROUP

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Small molecule inhibitors are a type of molecules that can interact with proteins and reduce the biological activity of target proteins, including enzyme inhibitors, transcription factor inhibitors, and ion channel blockers. It acts on popular signaling pathways, popular targets and popular research fields: MAPK, PI3K, JAK / STAT and other signaling pathways, HDAC, Aurora kinase, CDK and cell cycle regulators, integrase / protease, etc. Research fields such as epigenetics, CNS, GPCR, anti-virus, antibacterial / anti-inflammatory. It is an effective tool for cell biology research.

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Inhibitors

5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol

5,6-Dimethylxanthenone-4-acetic acid

5-Hydroxymethyltolterodine

5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine

5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one

Source Inhibitors Products Supply

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5-dimethoxyphenylamide

5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine

5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE

5-Carboxy-8-hydroxyquinoline

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