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Home > Biochemical Engineering > Inhibitors (Find 73 items)

Inhibitors

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ABT 199

(1257044-40-8)
Venetoclax has high affinity for BCL-2, binding to the protein with an affinity more than three orders of magnitude greater than to BCL-XL or BCL-W in vitro. By binding to BCL-2, the drug displaces BCL-2-bound proapoptotic proteins (such as BIM), resulting in the permeabilization of mitochondrial outer membranes, activation of caspases, and restoration of cancer cell apoptosis, with this process requiring the apoptosis regulators BAX or BAK.

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Afatinib dimaleate

(850140-73-7)
Afatinib dimaleate is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.

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Aliskiren hemifumarate

(173334-58-2)
An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive.

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Alectinib

(1256580-46-7)
CH5424802 is a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.CH5424802 have been clinically evaluated for the treatment of patients with ALK-driven tumors.

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Anagrelide hydrochloride

(58579-51-4)
Signal Transduction Agents, Potent PDE3 inhibitor

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Apalutamide

(956104-40-8)
Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM.

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ABT 263

(923564-51-6)
A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate.

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Small molecule inhibitors are a type of molecules that can interact with proteins and reduce the biological activity of target proteins, including enzyme inhibitors, transcription factor inhibitors, and ion channel blockers. It acts on popular signaling pathways, popular targets and popular research fields: MAPK, PI3K, JAK / STAT and other signaling pathways, HDAC, Aurora kinase, CDK and cell cycle regulators, integrase / protease, etc. Research fields such as epigenetics, CNS, GPCR, anti-virus, antibacterial / anti-inflammatory. It is an effective tool for cell biology research.

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