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Home > Biochemical Engineering > Inhibitors (Find 41 items)

Inhibitors

Dalcetrapib

(211513-37-0)
Dalcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor. Dalcetrapib is a drug undergoing trials for the treatment of cardiovascular disease, dyslipidemia, peripheral arterial disease (PAD).

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Dolutegravir sodium

(1051375-19-9)
ChEBI: An organic sodium salt that is the monosodium salt of dolutegravir. Used for treatment of HIV-1.

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Divalproex sodium

(76584-70-8)
Antiepileptic;Anticonvulsant that also acts as a mood stabilizer for those with bipolar disorder.

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DIBENZAZEPINE

(209984-56-5)
γ-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Aβ), a 39- to 42-amino acid peptide which forms the amyloid plaques that are characteristic of Alzheimer’s disease. DBZ is a dipeptidic inhibitor of γ-secretase that potently blocks the cleavage of Notch into its active signaling effector, Notch intracellular

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Dacinostat

(404951-53-7)
Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.

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Defactinib

(1073154-85-4)
Defactinib is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities.

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Delanzomib

(847499-27-8)
Delanzomib is an orally active proteasome inhibitor. Delanzomib has been shown to down-modulate NF-Wei B, induce apoptosis, inhibit angiogenesis and M-CSF-RANKL-induced osteoclastogenesis.

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Danoprevir

(850876-88-9)
Danoprevir is a NS3/4A protease inhibitor for hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM. The inhibition effect on HCV genotypes 1A/1B/4/5/6 is approximately 10-fold higher than 2B/3A.

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Small molecule inhibitors are a type of molecules that can interact with proteins and reduce the biological activity of target proteins, including enzyme inhibitors, transcription factor inhibitors, and ion channel blockers. It acts on popular signaling pathways, popular targets and popular research fields: MAPK, PI3K, JAK / STAT and other signaling pathways, HDAC, Aurora kinase, CDK and cell cycle regulators, integrase / protease, etc. Research fields such as epigenetics, CNS, GPCR, anti-virus, antibacterial / anti-inflammatory. It is an effective tool for cell biology research.

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