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Home > Biochemical Engineering > Inhibitors (Find 42 items)

Biochemical Engineering

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Inhibitors

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Inhibitors

GSK2636771

(1372540-25-4)
GSK2636771 is a potent, selective and oral inhibitor of PI3Kβ with a Ki of 0.89 nM and an IC50 of 5.2 nM, showing 900-fold selectivity over p110α and p110γ, and 10-fold selectivity over p110δ isoforms.

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Golvatinib (E7050)

(928037-13-2)
Golvatinib is a potent and orally available inhibitor of c-MET and VEGFR-2 that exhibits potential antitumor properties by suppressing the overexpression of these receptor tyrosine kinases.

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Gandotinib

(1229236-86-5)
Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM. Gandotinib (LY2784544) also inhibits FLT3, FLT4, FGFR2, TYK2, and TRKB with IC50 of 4, 25, 32, 44, and 95 nM.

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GNF 5837

(1033769-28-6)

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Guanidine, N-hydroxy-, sulfate (2:1)

(6345-29-5)
Reacts with NO forming anadduct which is a potent and stable vasodilator.Its actions are very similar to those of NG-Hydroxy-L-arginine on the potentiation and stabilization of NO

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GSK 343

(1346704-33-3)
GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM in a cell-free assay, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases.

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GW788388

(452342-67-5)
GW788388 is a new TGF-beta type I receptor inhibitor with a much improved pharmacokinetic profile compared with SB431542.

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GSK-3BETA INHIBITOR XII

(601514-19-6)
Acts as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition.

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Ganetespib

(888216-25-9)
Ganetespib is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines.

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GSK 2334470

(1227911-45-6)

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Small molecule inhibitors are a type of molecules that can interact with proteins and reduce the biological activity of target proteins, including enzyme inhibitors, transcription factor inhibitors, and ion channel blockers. It acts on popular signaling pathways, popular targets and popular research fields: MAPK, PI3K, JAK / STAT and other signaling pathways, HDAC, Aurora kinase, CDK and cell cycle regulators, integrase / protease, etc. Research fields such as epigenetics, CNS, GPCR, anti-virus, antibacterial / anti-inflammatory. It is an effective tool for cell biology research.

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