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Home > Biochemical Engineering > Inhibitors (Find 56 items)

Biochemical Engineering

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Inhibitors

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Inhibitors

Liproxstatin-1

(950455-15-9)

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LY310762

(192927-92-7)
5-HT 1D -preferring receptor antagonist (EC 50 = 31 nM). Displays no activity on 5-HT transport.

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LDN-193189 HCl

(1062368-62-0)
LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive,

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L-Valyl-L-valine

(3918-94-3)

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Lurbinectedin

(497871-47-3)

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LY2584702

(1082949-67-4)

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LY2228820

(862507-23-1)
LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. LY2228820 significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events.

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ly2603618IC-83

(911222-45-2)
LY2603618 is a potent and selective inhibitor of Chk1 with an IC50 of 7 nM.

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LDN212854

(1432597-26-6)
LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.

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LFM-A13

(244240-24-2)

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Small molecule inhibitors are a type of molecules that can interact with proteins and reduce the biological activity of target proteins, including enzyme inhibitors, transcription factor inhibitors, and ion channel blockers. It acts on popular signaling pathways, popular targets and popular research fields: MAPK, PI3K, JAK / STAT and other signaling pathways, HDAC, Aurora kinase, CDK and cell cycle regulators, integrase / protease, etc. Research fields such as epigenetics, CNS, GPCR, anti-virus, antibacterial / anti-inflammatory. It is an effective tool for cell biology research.

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