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Inhibitors

NLG919

(1402836-58-1)

NLG919 SDS

- / 99.00%

LEAP CHEM CO., LTD.
Pharmacy Grade / 99%

TIANYUAN PHARMACEUTICAL CO.,LIMITED
Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD

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N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide

(717907-75-0)

A potent, ATP-competitive and reversible inhibitor of FAK and Pyk2 catalytic activity with IC50s of 1.5 nM and 14 nM, respectively.

N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide SDS

industrial Grade / 98%

Hangzhou KieRay Chem Co.
HANGZHOU JHECHEM CO LTD
Conier Chem&Pharma Limited
ATK CHEMICAL COMPANY LIMITED

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N-[(1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]octanamide

(491833-29-5)

Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM.

N-[(1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]octanamide SDS

- / 99.00%

LEAP CHEM CO., LTD.
Pharmaceutical Grade / 99%

$100/KG EXW

Shandong Airuike Chemical Co., Ltd.
- / 95%

Shaanxi Dideu Medichem Co. Ltd
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD

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NVP-BEP800

(847559-80-2)

NVP-BEP800 SDS

- / 0.98%

Creative Enzymes
IndustrialGrade / 99.00%

Shaanxi Dideu Medichem Co. Ltd
Dayang Chem (Hangzhou) Co.,Ltd
LEAP CHEM CO., LTD.

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N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]acetamide

(593960-11-3)

PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM, and also inhibits PI3Kγ and PI3Kα with IC50 of 16 nM and 39 nM, respectively.

N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]acetamide SDS

- / 99.00%

LEAP CHEM CO., LTD.
Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD
HANGZHOU JHECHEM CO LTD

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N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine

(1097917-15-1)

N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine SDS

Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
Dayang Chem (Hangzhou) Co.,Ltd
LEAP CHEM CO., LTD.
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD

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N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide

(1346574-57-9)

GSK126 is a potent and highly selective S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase enzyme activity. The inhibition activity of GSK126 on EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma.

N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide SDS

- / 99.00%

LEAP CHEM CO., LTD.
- / 95%

Creative Enzymes
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD
HANGZHOU JHECHEM CO LTD

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N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide

(1214265-57-2)

WZ8040 is an irreversiblely EGFR T790M inhibitor (IC50<10nM).

N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide SDS

Creative Enzymes
Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
LEAP CHEM CO., LTD.
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD

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Nepicastathydrochloride

(170151-24-3)

Nepicastat Hcl(SYN117 Hcl; RS-25560-197 Hcl) is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively. IC50 value: 8.5/9.0 nM(bovine/human dopamine beta-hydroxylase)Dopamine beta-hydroxylase is an enzyme that catalyzes the conversion of dopamine to norepinephrine. Nepicastat (SYN117; RS-25560-197) has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated as such.

Nepicastathydrochloride SDS

- / 99%

Creative Enzymes
Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
LEAP CHEM CO., LTD.
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD

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N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide

(1431612-23-5)

The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. UNC1999 is a cell-permeable EZH2 inhibitor (IC50 = 2 nM) that is 22-fold selective over EZH1 and >1,000-fold selective over other histone methytranferases.UNC1999 has been shown to inhibit H3K27 methylation in MCF10A cells with an IC50 value of 124 nM.[Cayman Chemical]

N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide SDS

Pharmacy Grade / 99%

Changzhou Xuanming Pharmaceutical Techno
Industrial Grade / 99%

Shaanxi Dideu Medichem Co. Ltd
LEAP CHEM CO., LTD.
Industrial Grade / 99%

CHEMLYTE SOLUTIONS CO.,LTD

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Small molecule inhibitors are a type of molecules that can interact with proteins and reduce the biological activity of target proteins, including enzyme inhibitors, transcription factor inhibitors, and ion channel blockers. It acts on popular signaling pathways, popular targets and popular research fields: MAPK, PI3K, JAK / STAT and other signaling pathways, HDAC, Aurora kinase, CDK and cell cycle regulators, integrase / protease, etc. Research fields such as epigenetics, CNS, GPCR, anti-virus, antibacterial / anti-inflammatory. It is an effective tool for cell biology research.

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Inhibitors

NLG919

N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide

N-[(1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]octanamide

NVP-BEP800

N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]acetamide

N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine

N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide

N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide

Nepicastathydrochloride

N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide

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