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Inhibitors

N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N′-[4-(dimethylamino)phenyl]urea

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively; exhibits 50-fold selectivity over OX2 receptor.IC50 Value: 57 nM(Ki)Target: OX1 Receptorin vitro: SB-408124 binds hypocretin type 1 receptor (HcrtR1) with pKi values of 7.57. Calcium mobilization studies shows that SB-408124 is a functional antagonist of the OX1 receptor with a affinity of approximately 50-fold selectivity over the OX2 receptor. A recent study i

N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N′-[4-(dimethylamino)phenyl]urea SDS

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CHEMLYTE SOLUTIONS CO.,LTD
HANGZHOU JHECHEM CO LTD
Conier Chem&Pharma Limited

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N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide

(194423-06-8)

ChEBI: A member of the class of quinazolines that is 4,6-diaminoquinazoine in which the one of the hydrogens attached to the amino group at position 4 has been replaced by a m-bromophenyl group while one of the hydrogens attached to the amino group a position 6 has been replaced by a but-2-ynoyl group.

N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide SDS

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Dayang Chem (Hangzhou) Co.,Ltd
LEAP CHEM CO., LTD.
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N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide

(677338-12-4)

PIK-90 is a DNA-PK and PI3K inhibitor, which inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.

N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide SDS

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LEAP CHEM CO., LTD.
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HANGZHOU JHECHEM CO LTD

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Nexturastat A

(1403783-31-2)

Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.IC50 value: 5 nM [1]Target: HDAC6 inhibitorNexturastat A displayed low micromolar activity compared to the low nanomolar activity against HDAC6. Moreover, it also demonstrated high levels of selective inhibition against members of the related Class 2 HDAC isozymes reaching >1000-fold selective in some cases. Compared to the pan-selective HDACI LBH589, Nexturastat A is approximatel

Nexturastat A SDS

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Creative Enzymes
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Shaanxi Dideu Medichem Co. Ltd
Dayang Chem (Hangzhou) Co.,Ltd

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N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

(55778-02-4)

N1,N4-di-2-Pyridinyl-1,4-benzenedimethanamine acts as an inhibitor for the chemokine receptor CXCR4.

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine SDS

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henan kanbei chemical co.,ltd
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Shaanxi Dideu Medichem Co. Ltd
LEAP CHEM CO., LTD.
HANGZHOU JHECHEM CO LTD

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N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide

(1355326-35-0)

AGI5198 inhibits mutant IDH1 (isocitrate dehydrogenase 1) in cancer cells which delays growth and promotes differentiation of the glioma cells.

N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide SDS

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LEAP CHEM CO., LTD.
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HANGZHOU JHECHEM CO LTD

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NSC 23766 (hydrochloride)

(1177865-17-6)

NSC 23766 is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.

NSC 23766 (hydrochloride) SDS

Creative Enzymes
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N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)urea

(501925-31-1)

PNU-120596 (NSC 216666 ) is a potent and selective positive allosteric α7 nAChR modulator with an EC50 of 0.2 μM.IC50 value: 0.2 uM (EC50) [1] Target: α7in vitro: PNU-120596 increases agonist (Ach)-evoked calcium flux mediated by an engineered variant of the human α7 nAChR. PNU-120596 increases agonists (choline and ACh)-evoked currents mediated by wild-type receptors and also demonstrates a pronounced prolongation of the evoked response in the continued presence of agonist in Xenopus oo

N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)urea SDS

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Shaanxi Dideu Medichem Co. Ltd
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HANGZHOU JHECHEM CO LTD

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N-(4-Mesitylthiazol-2-yl)benzaMide

(1001753-24-7)

INH6 is a potent Nek2/Hec1 inhibitor; inhibits the growth of HeLa cells with an IC50 of 2.4 μM.

N-(4-Mesitylthiazol-2-yl)benzaMide SDS

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Dayang Chem (Hangzhou) Co.,Ltd
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NMS-P937 (NMS1286937)

(1034616-18-6)

NMS-P937 (NMS1286937) SDS

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Shaanxi Dideu Medichem Co. Ltd
Dayang Chem (Hangzhou) Co.,Ltd
LEAP CHEM CO., LTD.
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Small molecule inhibitors are a type of molecules that can interact with proteins and reduce the biological activity of target proteins, including enzyme inhibitors, transcription factor inhibitors, and ion channel blockers. It acts on popular signaling pathways, popular targets and popular research fields: MAPK, PI3K, JAK / STAT and other signaling pathways, HDAC, Aurora kinase, CDK and cell cycle regulators, integrase / protease, etc. Research fields such as epigenetics, CNS, GPCR, anti-virus, antibacterial / anti-inflammatory. It is an effective tool for cell biology research.

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Inhibitors

N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N′-[4-(dimethylamino)phenyl]urea

N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide

N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide

Nexturastat A

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide

NSC 23766 (hydrochloride)

N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)urea

N-(4-Mesitylthiazol-2-yl)benzaMide

NMS-P937 (NMS1286937)

Source Inhibitors Raw Materials by Region

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