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Home > Biochemical Engineering > Inhibitors (Find 1083 items)

Inhibitors

Silodosin

(160970-54-7)
Silodosin(Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity. It causes practically no orthostatic hypotension (in contrast to other α1 blockers). Since Silodosin is a highly selective inhibitor of the α1A adrenergic receptor, it causes pr

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Palonosetron hydrochloride

(135729-62-3)
1. Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
2. Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting
3. Specifically inhibits cells of the adrenal cortex and their production of hormones for adrenocortical tumor therapy, causes CNS damage, but no bone marrow depression.
4. Palonosetron is a potent, selective antagonist of t

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Ranolazine

(95635-55-5)
Ranolazineis an anti-ischemic agent which modulates myocardial metabolism. Antianginal.

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Mirtazapine

(85650-52-8)
An α2-Adrenergic blocker; analogue of Mianserin. Antidepressant.

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Azathioprine

(446-86-6)
An immunosuppressive antimetabolite.Also active as disease modifying antirheumatic drug (DMARD). Azathioprine is a purine analog with immunosuppressive effects.

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Bosentan

(147536-97-8)
A mixed endothelin receptor antagonist. Used as a vasodilator. Antihypertensive.

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Olaparib

(763113-22-0)
Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 μM). It can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block B

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Rimonabant

(168273-06-1)
Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane

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Lenvatinib

(417716-92-8)
E7080 (Lenvatinib) is a multi-target inhibitor of VEGFR2 and VEGFR3 with IC50 of 4 nM and 5.2 nM, respectively.

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Duloxetine hydrochloride

(136434-34-9)
solubility H2O: soluble5 mg/mL (clear solution, warmed)

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Small molecule inhibitors are a type of molecules that can interact with proteins and reduce the biological activity of target proteins, including enzyme inhibitors, transcription factor inhibitors, and ion channel blockers. It acts on popular signaling pathways, popular targets and popular research fields: MAPK, PI3K, JAK / STAT and other signaling pathways, HDAC, Aurora kinase, CDK and cell cycle regulators, integrase / protease, etc. Research fields such as epigenetics, CNS, GPCR, anti-virus, antibacterial / anti-inflammatory. It is an effective tool for cell biology research.

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