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Home > Biochemical Engineering > Inhibitors (Find 1083 items)

Biochemical Engineering

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Inhibitors

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Inhibitors

Atomoxetine

(83015-26-3)
A compound active at novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases.

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Enzalutamide

(915087-33-1)
Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM

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Paliperidone

(144598-75-4)
Paliperidone(Invega) is an atypical antipsychotic. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone. It is indicated for the acute and maintenance treatment of schizophrenia

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Fexofenadine hydrochloride

(153439-40-8)
Fexofenadine is a non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki value of 10 nM and exhibits anti-inflammatory effects. It is devoid of central nervous system effects in part because it is a good substrate for the P-glycoprotein efflux pump situated within the blood-brain barrier.[Cayman Chemical]

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Estradiol cypionate

(313-06-4)
estrogen

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Apremilast

(608141-41-9)
Apremilast , an oral phosphodiesterase 4 inhibitor is used in the treatment of psoriatic arthritis.

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Cabozantinib

(849217-68-1)
Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively

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Olopatadine hydrochloride

(140462-76-6)
Olopatadine is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively). It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg). Olopatadine is effective in treating allergic rhinitis and conjunctivitis. It al

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Ivabradine hydrochloride

(148849-67-6)
Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal

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Synephrine hydrochloride

(5985-28-4)
A 伪-adrenergic receptor agonist, vasoconstrictor.

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Small molecule inhibitors are a type of molecules that can interact with proteins and reduce the biological activity of target proteins, including enzyme inhibitors, transcription factor inhibitors, and ion channel blockers. It acts on popular signaling pathways, popular targets and popular research fields: MAPK, PI3K, JAK / STAT and other signaling pathways, HDAC, Aurora kinase, CDK and cell cycle regulators, integrase / protease, etc. Research fields such as epigenetics, CNS, GPCR, anti-virus, antibacterial / anti-inflammatory. It is an effective tool for cell biology research.

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