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Home > Biochemical Engineering > Inhibitors (Find 1083 items)

Biochemical Engineering

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Inhibitors

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Inhibitors

Tasquinimod

(254964-60-8)
Tasquinimod is an oral antiangiogenic agent in clinical trials for the treatment of castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM.

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Splitomicin

(5690-03-9)
Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD+-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC50 of 60 μM[1].

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5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]

(1062368-49-3)

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SCH772984

(942183-80-4)
SCH772984 potently inhibits ERK1 and ERK2 activity with IC50s of 4 and 1 nM, respectively.

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FLI-06

(313967-18-9)
FLI-06 is an inhibitor of Notch signaling with an EC50 of 2.3 μM.

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Palomid 529

(914913-88-5)
Palomid 529 is a potent inhibitor of mTORC1 and mTORC2 complexes.

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Urechistachykinin II

(149097-04-1)

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(1R,2R)-2-[[4′-[[(Phenylamino)carbonyl]amino][1,1′-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid

(959122-11-3)
A 922500 is a potent, selective, and orally bioavailable DGAT-1 inhibitor exhibiting IC50s of 9 and 22 nM against human and mouse DGAT-1, respectively.

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P276

(920113-03-7)

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Resminostat

(864814-88-0)
Resminostat is a potent inhibitor of HDAC1, HDAC3 and HDAC6, with mean IC50 values of 42.5, 50.1, 71.8 nM, respectively, and shows less potent activities against HDAC8, with an IC50 of 877 nM.

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Small molecule inhibitors are a type of molecules that can interact with proteins and reduce the biological activity of target proteins, including enzyme inhibitors, transcription factor inhibitors, and ion channel blockers. It acts on popular signaling pathways, popular targets and popular research fields: MAPK, PI3K, JAK / STAT and other signaling pathways, HDAC, Aurora kinase, CDK and cell cycle regulators, integrase / protease, etc. Research fields such as epigenetics, CNS, GPCR, anti-virus, antibacterial / anti-inflammatory. It is an effective tool for cell biology research.

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