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Home > Biochemical Engineering > Inhibitors (Find 1083 items)

Inhibitors

Tie2 kinase inhibitor

(948557-43-5)
Tunica interna endothelial cell kinase 2 (Tie2, also known as angiopoietin-1 receptor or tek) is an endothelium-specific receptor tyrosine kinase important for the development of embryonic vasculature and for angiogenesis and vascular maintenance in adult tissues. Tie2 kinase inhibitor reversibly and selectively blocks Tie2 kinase activity with an IC50 value of 250 nM. It is 200-fold more potent for inhibition of Tie2 compared to p38. Tie2 kinase inhibitor has been shown to reduce angiogenesis i

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1-[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carboxylic acid

(79994-24-4)

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Small cardioactive peptide B

(84746-43-0)

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Histidylglycine

(2578-58-7)
ChEBI: A dipeptide formed from L-histidine and glycine residues.

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PD 151746

(179461-52-0)
PD151746 is a calpain inhibitor, shows a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM).IC50 value: 0.26 ± 0.03 μM (Ki, for μ-calpain), 5.33 ± 0.77 μM (Ki, for m-calpain) [1]Target: calpainin vitro: The μ-calpain inhibitor PD 151746 decreases oxLDL-induced cytotoxicity. [2]

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TAE226 (NVP-TAE226)

(761437-28-9)
NVP-TAE 226 is a dual tyrosine kinase inhibitor of FAK (IC50=5.5 nM) and IGF-IR (mean IC50=0.14 μM).

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Small molecule inhibitors are a type of molecules that can interact with proteins and reduce the biological activity of target proteins, including enzyme inhibitors, transcription factor inhibitors, and ion channel blockers. It acts on popular signaling pathways, popular targets and popular research fields: MAPK, PI3K, JAK / STAT and other signaling pathways, HDAC, Aurora kinase, CDK and cell cycle regulators, integrase / protease, etc. Research fields such as epigenetics, CNS, GPCR, anti-virus, antibacterial / anti-inflammatory. It is an effective tool for cell biology research.

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