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Home > Organic Chemistry > Lactones (Find 11 items)

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Lactones

MTS

(35846-53-8)
Antineoplastic.

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Maytansinoid DM 1

(139504-50-0)
Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.

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Maytansinol (7)

(57103-68-1)
Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.Target: Microtubule/Tubulinin vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis i

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Methymycin

(497-72-3)

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mycotrienolI

(81904-15-6)

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Source Lactones Products Supply

monactin

(7182-54-9)
Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Monactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and IFN-γ.

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Milbemycin D

(77855-81-3)
Milbemycins are a complex family of macrocyclic lactones containing a highly characteristic spiroketal group, produced by Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycin D is a minor member of a group of analogues containing a 25-isopropyl substituent. Milbemycin D is a highly selective and potent nematocide and insecticide. Like the closely related avermectin, milbemycins are thought to act on chloride-gated ion channels.

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Monocerin

(30270-60-1)
ChEBI: A natural product found in Colletotrichum species.

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Malolactomycin A

(135667-47-9)

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Malolactomycin D

(189759-06-6)

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Lactone refers to an organic substance that contains both a carboxyl group and a hydroxyl group in the same molecule, and the two are dehydrated. Organic compounds with one and only one ester group in the ring. Common ones are x=2, 3 or 4, which are called β-, γ- or δ-lactones, respectively. They are generally insoluble in water, easily soluble in organic solvents such as ethanol and ether, and their density is generally lower than that of water.

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