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Lactones

Bryostatin 1

(83314-01-6)

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Solithromycin

(760981-83-7)

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Concanamycin B

(81552-33-2)
Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A. Like other concanamycins and bafilomycins, concanamycin B inhibits vacuolar H(+)-ATPase. Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules and suppresses bone resorption in vitro.

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Lactone refers to an organic substance that contains both a carboxyl group and a hydroxyl group in the same molecule, and the two are dehydrated. Organic compounds with one and only one ester group in the ring. Common ones are x=2, 3 or 4, which are called β-, γ- or δ-lactones, respectively. They are generally insoluble in water, easily soluble in organic solvents such as ethanol and ether, and their density is generally lower than that of water.
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