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Home > Organic Chemistry > Lactones (Find 240 items)

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Elementary Substance

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Lactones

Venturicidin

(33538-72-6)
The macrolide antibiotic Venturicidin B, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. Venturicidin A was originally isolated as an antifungal agent.

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Apoptolidin

(194874-06-1)
Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action.

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N-(2,3-Dimethylphenyl)acetamide

(134-98-5)

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1,8-Dioxacycloheptadecan-9-one

(1725-01-5)

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(3R,4S,5S,7R,9E,11R,12S)-12-[(1R)-1-Hydroxyethyl]-3,5,7,11-tetramethyl-4-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclododec-9-ene-2,8-dione

(497-73-4)
ChEBI: A twelve-membered macrolide antibiotic that is biosynthesised by Streptomyces venezuelae.

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Amphotericin A

(1405-32-9)

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(3E,8S,11E,16S)-8,16-Bis(2-oxopropyl)-1,9-dioxacyclohexadeca-3,11-diene-2,5,10,13-tetrone

(37244-00-1)

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aerocavin

(113702-00-4)

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(+)-Bryostatin 2

(87745-28-6)

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(6R,25R)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-methylmilbemycin B

(51596-10-2)

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Lactone refers to an organic substance that contains both a carboxyl group and a hydroxyl group in the same molecule, and the two are dehydrated. Organic compounds with one and only one ester group in the ring. Common ones are x=2, 3 or 4, which are called β-, γ- or δ-lactones, respectively. They are generally insoluble in water, easily soluble in organic solvents such as ethanol and ether, and their density is generally lower than that of water.

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