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Home > Biochemical Engineering > Polypeptide (Find 21 items)

Polypeptide

Polypeptides are vital biomolecules with broad applications in biology and industry. It is composed of amino acids linked by polypeptide bonds. These polypeptide chains form the backbone of most proteins and are key to cellular functions, enzyme regulation, and structural support. Their efficiency makes them valuable in biotechnology, medicine, and manufacturing. Learn more about polypeptides, including CAS No., properties, and information of materials and products from our suppliers on ECHEMI.

N2-(1-Oxotetradecyl)-L-lysyl-L-alanyl-L-lysyl-L-alaninamide

(959610-24-3)

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NEUROKININ B

(86933-75-7)
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs—including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

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NEUROKININ A

(86933-74-6)
Neurokinin A acts via neurokinin 2 (NK-2) receptor.

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NEUROPEPTIDEY(HUMAN,RAT)

(90880-35-6)
Neuropeptide Y (29-64), amide, human is a biologically active 36-amino acid peptide.

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N-Acetylaspartylglutamic acid

(3106-85-2)
Spaglumic Acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.

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N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide

(123653-11-2)
Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .

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NEUROPEPTIDE FF

(99566-27-5)
Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, interacts with two distinct G-protein-coupled receptors, NPFF(1) and NPFF(2) and has wide variety of physiological functions in the brain including central cardiovascular and neuroendocrine regulation[1][2].

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N2-(1-Oxohexadecyl)-L-lysyl-L-valyl-(2S)-2,4-diaminobutanoyl-L-threonine bis(trifluoroacetate) (salt)

(883558-32-5)

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Polypeptide is a compound formed by connecting α-amino acids with peptide bonds, and is an intermediate product of protein hydrolysis. Compounds usually formed by the dehydration and condensation of 10 to 100 amino acid molecules are called peptides. There are two types of peptides: biologically active peptides and synthetic peptides.

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Application of polypeptide

With recent advancements in biotechnology, polypeptides have found increasing use as therapeutic agents. They can serve in diagnostic, curative, and preventative applications and can be synthesized artificially to meet clinical demands.

Due to their unique properties, polypeptides combine the characteristics of both small molecule drugs and protein-based therapies, making them a highly researched class of molecules. Insulin, for example, was the first polypeptide drug introduced, and since then, over 80 polypeptide-based drugs have been commercialized. These include peptide vaccines, anti-cancer peptides, antiviral peptides, cardiovascular peptides, cytokine mimetic peptides, antimicrobial peptides, and diagnostic peptides.

One of the major advantages of polypeptide drugs is their reduced likelihood of inducing drug resistance. However, they also pose significant challenges, such as higher toxicity and lower stability compared to other drug types. The immunogenicity and instability of polypeptide drugs are often attributed to chemical reactions like deamidation, oxidation, hydrolysis, and the formation of incorrect structures.

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