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Home > Biochemical Engineering > Polypeptide (Find 624 items)

Polypeptide

Polypeptides are vital biomolecules with broad applications in biology and industry. It is composed of amino acids linked by polypeptide bonds. These polypeptide chains form the backbone of most proteins and are key to cellular functions, enzyme regulation, and structural support. Their efficiency makes them valuable in biotechnology, medicine, and manufacturing. Learn more about polypeptides, including CAS No., properties, and information of materials and products from our suppliers on ECHEMI.

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Azilsartan

(147403-03-0)
Azilsartan is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM

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Linaclotide

(851199-59-2)
Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.

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Soybean Peptide

(107761-42-2)
Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

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Seractide

(12279-41-3)
Hormone (adrenocorticotropic).

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Pramlintide acetate

(196078-30-5)
An analogue of human amylin used in the treatment of insulin dependent diabetes.

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Pramlintide

(151126-32-8)

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Enfuvirtide

(159519-65-0)
Enfuvirtide is an anti-HIV-1 fusion inhibitor peptide. Sequence: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2.

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Polypeptide is a compound formed by connecting α-amino acids with peptide bonds, and is an intermediate product of protein hydrolysis. Compounds usually formed by the dehydration and condensation of 10 to 100 amino acid molecules are called peptides. There are two types of peptides: biologically active peptides and synthetic peptides.

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Application of polypeptide

With recent advancements in biotechnology, polypeptides have found increasing use as therapeutic agents. They can serve in diagnostic, curative, and preventative applications and can be synthesized artificially to meet clinical demands.

Due to their unique properties, polypeptides combine the characteristics of both small molecule drugs and protein-based therapies, making them a highly researched class of molecules. Insulin, for example, was the first polypeptide drug introduced, and since then, over 80 polypeptide-based drugs have been commercialized. These include peptide vaccines, anti-cancer peptides, antiviral peptides, cardiovascular peptides, cytokine mimetic peptides, antimicrobial peptides, and diagnostic peptides.

One of the major advantages of polypeptide drugs is their reduced likelihood of inducing drug resistance. However, they also pose significant challenges, such as higher toxicity and lower stability compared to other drug types. The immunogenicity and instability of polypeptide drugs are often attributed to chemical reactions like deamidation, oxidation, hydrolysis, and the formation of incorrect structures.

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