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Nizofenone

Nizofenone structure

CAS No:
54533-85-6
Formula:
C21H21ClN4O3
Chemical Name:
Nizofenone
Synonyms:
Methanone,(2-chlorophenyl)[2-[2-[(diethylamino)methyl]-1H-imidazol-1-yl]-5-nitrophenyl]-;(2-Chlorophenyl)[2-[2-[(diethylamino)methyl]-1H-imidazol-1-yl]-5-nitrophenyl]methanone;1-[2-(2-Chlorobenzoyl)-4-nitrophenyl]-2-[(diethylamino)methyl]imidazole;Nizofenone
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

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Description

Nizofenone is a member of benzophenones.

Nizofenone Basic Attributes

Molecular Weight：

412.87

Exact Mass：

412.87

UNII：

7A2NOC3R88

DSSTox ID：

DTXSID5048637

ATC Code：

N - Nervous system

HScode：

2933290090

Characteristics

PSA：

XLogP3：

4.25

Density：

1.3±0.1 g/cm3

Melting Point：

75-76 °C

Boiling Point：

609.7±65.0 °C at 760 mmHg

Flash Point：

322.5±34.3 °C

Refractive Index：

1.623

Drug Information

MeSH：

Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)|Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

MeSH Entry Terms：

1-(2-(2-chlorobenzoyl)-4-nitrophenyl)-2-(diethylaminomethyl)imidazole

Nizofenone Use and Manufacturing

It can prolong the survival time of local and global cerebral ischemia models, global cerebral ischemia re-supply model and hypoxia model, and improve the brain function and shrink the cerebral embolism lesions. It is used for brain disorders caused by mild to moderate subarachnoid hemorrhage in the acute stage of ischemia.

Computed Properties

Molecular Weight:412.9
XLogP3:4.1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:412.1302182
Monoisotopic Mass:412.1302182
Topological Polar Surface Area:84
Heavy Atom Count:29
Complexity:569
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Magnesium sulfate heptahydrate

Sodium bicarbonate

Diisopropyl ether

1-Methylimidazole