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Bromperidol

Bromperidol structure

CAS No:
10457-90-6
Formula:
C21H23BrFNO2
Chemical Name:
Bromperidol
Synonyms:
1-Butanone,4-[4-(4-bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-;Butyrophenone,4-[4-(p-bromophenyl)-4-hydroxypiperidino]-4′-fluoro-;4-[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone;Bromoperidol;R 11333;Bromperidol;Tesoprel;Azurene;Impromen;Bromodol
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Tan Solid

Bromperidol is an aromatic ketone.|Bromperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.

Bromperidol Basic Attributes

Molecular Weight：

420.32

Exact Mass：

420.32

EC Number：

233-943-3

UNII：

LYH6F7I22E

NSC Number：

759275

DSSTox ID：

DTXSID0022690

ATC Code：

N05AD06|N - Nervous system

HScode：

2933399090

Characteristics

PSA：

40.5

XLogP3：

4.47260

Appearance：

white solid

Density：

1.3109 (estimate)

Melting Point：

155 °C

Boiling Point：

215.2°C (rough estimate)

Flash Point：

282.6ºC

Refractive Index：

1.59

Water Solubility：

H2O: insoluble

Storage Conditions：

Refrigerator

Toxicity：

Oral-rat LD50: 359 mg/kg; Oral-Mouse LD50: 174 mg/kg

Flammability characteristics：

Thermal decomposition emits toxic nitrogen oxides, bromide, fluoride fumes

Collision Cross Section：

194.9 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

RTECS Number：

EU1180000

Marks：

Storage features：

The warehouse is ventilated, low temperature and dry; stored separately from food raw materials

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P301+P312, P304+P312, P304+P340, P312, P330, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

Metabolism/Metabolites：

Bromperidol has known human metabolites that include 4'-Fluorobutyrophenone and 4-(4-Bromophenyl)piperidin-4-ol.

MeSH Entry Terms：

bromoperidol

Bromperidol Use and Manufacturing

Uses

analgesic, antiinflammatory

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:420.3
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:419.08962
Monoisotopic Mass:419.08962
Topological Polar Surface Area:40.5
Heavy Atom Count:26
Complexity:451
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes