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Mosapride

Mosapride structure

CAS No:
112885-41-3
Formula:
C21H25ClFN3O3
Chemical Name:
Mosapride
Synonyms:
Benzamide,4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-;4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamide;Mosapride;Moza;4-Amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide;144256-27-9
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

Description

Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.Target: 5HT4 Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist. The major active metabolite of mosapride, known as M1, additionally acts as a 5HT3 antagonist, which accelerates gastric emptying throughout the whole of the gastrointestinal tract in humans, and is used for the treatment of gastritis, gastro-oesophageal reflux disease, functional dyspepsia and irritable bowel syndrome. It i

Mosapride is a racemate comprising equimolar amounts of (R)- and (S)-mosapride. It is a gastroprokinetic agent which acts on 5-hydroxytryptamine type 4 (5-HT4) receptors in the gastrointestinal plexus, consequently increasing the release of acetylcholine and hence enhancing gastrointestinal motility and gastric emptying. It has a role as a gastrointestinal drug and a serotonergic agonist. It contains a (R)-mosapride and a (S)-mosapride.|Mosapride is under investigation for the treatment and prevention of Postoperative Ileus and Gastric Peroral Endoscopic Pyloromyotomy (G-POEM). Mosapride has been investigated for the treatment and diagnostic of Constipation, Type 2 Diabetes, Functional Dyspepsia, Functional Constipation, and Epigastric Pain Syndrome, among others.

Mosapride Basic Attributes

Molecular Weight：

421.89

Exact Mass：

421.89

EC Number：

601-210-0

DSSTox ID：

DTXSID2048408

ATC Code：

A - Alimentary tract and metabolism

HScode：

2934999090

Characteristics

PSA：

76.8

XLogP3：

2.8

Appearance：

White to Off-White Crystalline Solid

Density：

1.3±0.1 g/cm3

Melting Point：

151-153 °C @ Solvent: Ethanol

Boiling Point：

549.2°C at 760 mmHg

Flash Point：

286.0±30.1 °C

Refractive Index：

1.585

Storage Conditions：

-20°C Freezer

Vapor Pressure：

4.11E-12mmHg at 25°C

Safety Information

Packing level：

Hazard category：

Transport codes：

UN 3260 8/PG 2

wgk germany：

hazard class code：

R14:Reacts violently with water. R34:Causes burns. R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . R12:Extremely Flammable.

safety instructions：

S26-S27-S28-S36/37/39-S45-S61-S33-S29-S16

RTECS Number：

LW9100000

Marks：

C,N,F+

Drug Information

MeSH：

Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)|Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)

MeSH Entry Terms：

4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide

Mosapride Use and Manufacturing

gastroprokinetic agent

Computed Properties

Molecular Weight:421.9
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:421.1568475
Monoisotopic Mass:421.1568475
Topological Polar Surface Area:76.8
Heavy Atom Count:29
Complexity:521
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Mosapride

CAS No.: 112885-41-3

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Content: 98%

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