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Magnesium valproate

Magnesium valproate structure

CAS No:
62959-43-7
Formula:
C8H16O2.¹/2Mg
Chemical Name:
Magnesium valproate
Synonyms:
Pentanoic acid,2-propyl-,magnesium salt (2:1);Pentanoic acid,2-propyl-,magnesium salt;Magnesium dipropylacetate;Magnesium valproate;Dipromal;93460-17-4
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Magnesium Valproate is the magnesium salt of valproic acid (2-propylpentanoic acid) with antiepileptic and potential antineoplastic activities. Magnesium valproate dissociates in the gastrointestinal tract and is absorbed into the circulation as magnesium ions and valproic acid ions; valproic acid may inhibit histone deacetylases, inducing tumor cell differentiation, apoptosis, and growth arrest. In addition, valproic acid exerts an antiepileptic effect, likely by inhibiting enzymes that catabolize the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) catabolism and so increasing concentrations of GABA in the central nervous system (CNS). The presence of the magnesium in this agent may contribute to its anticonvulsant activity and sedative properties.|A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.

Magnesium valproate Basic Attributes

Molecular Weight：

310.71

Exact Mass：

310.199

EC Number：

263-770-9

UNII：

Q400352CM2

DSSTox ID：

DTXSID0041062

NCI Thesaurus Code：

C71156

Characteristics

PSA：

80.3

XLogP3：

4.42060

Appearance：

White powder

Boiling Point：

220ºC at 760 mmHg

Flash Point：

116.6ºC

Safety Information

Precautionary statement(s)：

P201, P202, P264, P270, P280, P281, P301+P312, P302+P352, P305+P351+P338, P308+P313, P321, P330, P332+P313, P337+P313, P362, P405, P501

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P280, P281, P301+P312, P302+P352, P305+P351+P338, P308+P313, P321, P330, P332+P313, P337+P313, P362, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that are used to treat bipolar disorders or mania associated with other affective disorders. (See all compounds classified as Antimanic Agents.)|Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)|Substances used for their pharmacological actions on GABAergic systems. GABAergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function. (See all compounds classified as GABA Agents.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

2 Propylpentanoic Acid

Magnesium valproate Use and Manufacturing

Antiepileptic

Computed Properties

Molecular Weight:310.71
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:310.1994511
Monoisotopic Mass:310.1994511
Topological Polar Surface Area:80.3
Heavy Atom Count:21
Complexity:87.9
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes