 Home > Encyclopedia > 5-Bromo-1,2-difluoro-3-methoxybenzene

5-Bromo-1,2-difluoro-3-methoxybenzene

5-Bromo-1,2-difluoro-3-methoxybenzene structure

CAS No:
261762-35-0
Formula:
C7H5BrF2O
Chemical Name:
5-Bromo-1,2-difluoro-3-methoxybenzene
Synonyms:
Benzene,5-bromo-1,2-difluoro-3-methoxy-;5-Bromo-1,2-difluoro-3-methoxybenzene;5-Bromo-2,3-difluoroanisole;1-Bromo-3,4-difluoro-5-methoxybenzene
Categories:
Organic Chemistry > Organic Fluorine Compound

Request for Quotation

Description

White crystalline powder

5-Bromo-1,2-difluoro-3-methoxybenzene Basic Attributes

Molecular Weight：

223.01

Exact Mass：

223.01

EC Number：

-0

DSSTox ID：

DTXSID30378340

HScode：

2909309090

Characteristics

PSA：

9.2

XLogP3：

2.8

Density：

1.6±0.1 g/cm3

Melting Point：

33-35°C

Boiling Point：

193.7°C at 760 mmHg

Flash Point：

84.6±10.2 °C

Refractive Index：

1.500

Storage Conditions：

Room temperature.

Vapor Pressure：

0.639mmHg at 25°C

Safety Information

Hazard category：

IRRITANT

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Hazard note：

Irritant

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 6 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

5-Bromo-1,2-difluoro-3-methoxybenzene Use and Manufacturing

To a solution of 81 (1.5 g, 7.1 mmol) and In a 3000 L reactor, 201.6 kg of KOH was added, Pumped 253.2 kg of 3, 4, 5-trifluorobromobenzene and 1500 L of methanol, Close the reaction kettle, stirring up to 60 , After 6 hours of reaction, Raw materials have been basically complete.The material into the crystallization pot with nitrogen into the pot, Stirring and cooling to -5 ° C, Insulation 5h filter, To give 2, 3-difluoro-5-bromoanisole, Yield 92.0percentContent of 99.2percent. The methanol recovery in the filtrate can be reused.A mixture of A flask is charged with 5-Bromo-1, 2-difluoro-3-methoxy-benzene (400 mg, 1.79 mmol, 1 eq.), piperazine (927 mg, 10.76 mmol, 6 eq.), BINAP (134 mg, 0.215 mmol, 0.12 eq.), NaOtBu (241 mg, 2.511 mmol, 1.4 eq.) and toluene (3 mL). The reaction mixture is degassed with N2 and Pd2(dba)3 (99 mg, 0.108 mmol, 0.06 eq.) is added. Reaction mixture is heated at 100C overnight. The reaction mixture is extracted with HCl 1N solution. The aqueous layer is basified with NaOH 2N solution and extracted with DCM. The combined organic layers are washed with water and brine, dried over anhydrous MgSO4, filtered and concentrated in vacuo to afford the expected product. LCMS: MW (calcd): 228. MW (obsd): 229 (M+H)A solution of 1-bromo-3, 4-difluoro-5-methoxy-benzene (1.11 g, 5.0 mmol, 1.0 eq.) and sodium methoxide (405 mg, 7.5 mmol, 1.5 eq.) in DMA (5 mL) is heated at 100C for 1h. The reaction mixture is then poured into 60 mL of water and ice, stirred and the resulting solid is filtered and dried under suction to afford the expected productA solution of 1-bromo-3, 4-difluoro-5-methoxy-benzene (1.11 g, 5.0 mmol, 1.0 eq.) and sodium methoxide (405 mg, 7.5 mmol, 1.5 eq.) in DMA (5 mL) is heated at 100C for lh. The reaction mixture is then poured into 60 ml. of water and ice, stirred and the resulting solid is filtered and dried under suction to afford the expected product.In a 50 mL round-bottom flask, introduce 1 g (4.48 mmol) of

Computed Properties

Molecular Weight:223.01
XLogP3:2.8
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:221.94918
Monoisotopic Mass:221.94918
Topological Polar Surface Area:9.2
Heavy Atom Count:11
Complexity:134
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 5-Bromo-1,2-difluoro-3-methoxybenzene

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

99% 5-Bromo-2,3-difluoroanisole CAS NO 261762-35-0 ISO 9001:2005 REACH Verified Producer

CAS No.: 261762-35-0

Grade: Industrial Grade

Content: 99%

Inquiry
henan kanbei chemical co.,ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of 1H,1H,2H,2H-PERFLUORODECYLTRIMETHOXYSILANE

high purity hot sale 5-bromo-2,3-difluoroanisole 99% high quality see COA KANBEI

CAS No.: 261762-35-0

Grade: Industrial Grade

Content: 99%

Inquiry

Latest News on 5-Bromo-1,2-difluoro-3-methoxybenzene

Learn More Other Chemicals

4-(Trifluoromethyl)benzeneacetic acid

32857-62-8
3-BROMO-2-FLUORO-6-PICOLINE

375368-78-8
2,4-Diisopropylphenol

2934-05-6
1,2-Diiodotetrafluoroethane Formula

354-65-4
6-METHYL-2-PIPERIDINECARBOXYLICACID Formula

99571-58-1
2,4-Dichloro-6-picoline Formula

42779-56-6
1-BROMO-1H,1H,2H,2H-PERFLUORODECANE Structure

21652-57-3
Perfluorohexanoic acid Structure

307-24-4
What is 6-chloro-2-naphthalenethiol

392330-26-6
What is 2,3-Dichloro-5-nitropyridine

22353-40-8

Hot Searches: cilostazol; alf3; naoh structure; ethyl acetate molar mass; ethyl acetate boiling point; methylene di-t-butylcresol cas no

Guide of 5-Bromo-1,2-difluoro-3-methoxybenzene

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
Learn More Other Chemicals

5-Bromo-1,2-difluoro-3-methoxybenzene

SDS

Request for Quotation



Complaint

Email:

Message:

Send Message