Cadmium sulfate

208.47

209.85500

233-331-6

947UNF3Z6O

1318

2570

DTXSID1020229

C45895

Colorless orthorhombic crystals|Rhombic, white crystals or prisms

88.6

White Powder

4.691 g/cm³

1000 °C

330ºC

INDEX OF REFRACTION 1.565

H2O: 1130 G/L (20 ºC)

Storage temperature: ambient; venting: open.

Oral-rat LD50: 280 mg/kg; Oral-Mouse LD50: 88 mg/kg

Thermal decomposition releases toxic sulfur oxides and cadmium fumes

Odorless

Enthalpy of fusion: 28 kJ/mol|Monoclinic crystals; mp 105 °C; density: 3.79 g/cu cm; solubility: 76.7 g/100 g water at 25 °C /Hydrate/|Colorless monoclinic crystals; mp 40 °C; density 3.08; solubility: 76.7 g/100 cc water at 25 °C /Octahydrate/|Magnetic susceptibility of cadmium sulfate is -49.7X10-6 cu cm/mol at /ambient/ temperature|pH of a 5% solution at 25 °C: 3.5-5.0. /Cadmium sulfate 8/3 hydrate/ 3CdSO4.8H2O/

Water soluble.

Salts, Acidic

CADMIUM SULFATE acts as a weakly acidic inorganic salt, which is soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

III

6.1

UN 2570 6.1/PG 3

3

45-46-60-61-25-26-48/23/25-50/53

53-45-60-61

EV2700000

T+,N

Treasury is ventilated, low temperature and dry; stored separately from food materials

Stable.

P201-P260-P273-P284-P301 + P310 + P330-P304 + P340 + P310

H301-H330-H340-H350-H360FD-H372-H410

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D006, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.|Peer-review: Soluble cadmium cmpd are converted to insoluble form, the sludge filtered, and deposited in a suitable landfill. Incineration of cadmium cmpd is not recommended because of the high sublimability of the oxide. (Peer-review conclusions of an IRPTC expert consultation (May 1985))|Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D006, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste. /Cadmium/|SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Dangerous Prop Ind Mater Rep 6 (6): 12-29 (1986). Review cadmium sulfate safety toxicol; health hazard of cadmium sulfate; safety of cadmium sulfate.|National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Cadmium and Cadmium Compounds are listed as known to be human carcinogens. /Cadmium and Cadmium Compounds/[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s028cadm.pdf]

Special Hazards of Combustion Products: Toxic cadmium oxide fume may form in fires. (USCG, 1999)

|Danger|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P264, P270, P271, P273, P281, P284, P301+P310, P304+P340, P308+P313, P310, P314, P320, P321, P330, P391, P403+P233, P405, and P501|H272 (10.26%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]|P201, P202, P210, P220, P221, P260, P264, P270, P271, P273, P280, P281, P284, P301+P310, P304+P340, P308+P313, P310, P314, P320, P321, P330, P370+P378, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P201, P202, P260, P264, P270, P271, P273, P280, P281, P284, P301+P310, P302+P352, P304+P340, P308+P313, P310, P312, P314, P320, P321, P322, P330, P363, P391, P403+P233, P405, and P501|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P280, P281, P301+P312, P302+P352, P305+P351+P338, P307+P311, P308+P313, P314, P321, P330, P332+P313, P337+P313, P362, P405, and P501|P201, P202, P260, P264, P270, P281, P301+P312, P308+P313, P314, P330, P405, and P501

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Bu. Mines approved respirator; rubber gloves; safety goggles (USCG, 1999)

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical or carbon dioxide. /Cadmium compounds, NOS/

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. All contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. /Cadmium compound/|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. /Cadmium compound/|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire: Small fires: Dry chemical, CO2 or water spray. Large fires: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. /Cadmium compound/|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. /Cadmium compound/|For more DOT Emergency Guidelines (Complete) data for CADMIUM SULFATE (8 total), please visit the HSDB record page.

Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.

Separated from food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.

A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

The substance is irritating to the respiratory tract.

The substance may have effects on the kidneys and bones. This may result in kidney impairment and osteoporosis (bone weakness). This substance is carcinogenic to humans.

PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!

Use local exhaust or breathing protection.

Protective gloves.

Wear safety goggles or eye protection in combination with breathing protection.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Cadmium sulfate is included on this list.

The major hazards encountered in the use and handling of cadmium sulfate stem from its toxicologic properties. Toxic primarily by ingestion and inhalation, exposure to this odorless, colorless-to-white, crystalline substance may occur from its use as a fungicide, a cement accelerator, and a chemical intermediate in the manufacture of plastic stabilizers and pigments. Effects from exposure may include headace, shortness of breath, chest pains, kidney damage, liver damage, emphysema, chronic bronchitis and pulmonary edema (possibly resulting in death). Processes and operations which may release cadmium fumes or dust should be enclosed and fitted with exhaust ventilation. In activities where over-exposure is possible, workers should wear a high efficiency particulate filter respirator or self-contained breathing apparatus. Protective clothing also should be worn. Preferably this should include disposable one-piece suits (close-fitting at ankles and wrists), gloves, hair covering, and overshoes. These should be removed before leaving work. If contact should occur, immediately wash contaminated skin with large amounts of water. Do not eat, smoke, or drink in work areas. Cadmium sulfate presents only a moderate fire hazard (when in the form of dust) if exposed to heat, flame, or by chemical reaction with oxidizing agents, metals, hydrogen azide, zinc, selenium, or tellurium. Wear a self-contained breathing apparatus when fighting such fires. Cadmium sulfate should be stored in cool, well-ventilated areas, out of direct rays of the sun, and away from fire hazards. If hazardous concentrations of cadmium sulfate are accidentally released, remove all ignition sources, ventilate the area, and collect the released material in closed containers for disposal. Before implementing land disposal of waste cadmium sulfate, consult environmental regulatory agencies for guidance.

D006; A waste containing cadmium may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Cadmium/

D006; A solid waste containing cadmium may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Cadmium/

highly toxic

Cd-sulphate and a 38% dimethoate containing insecticide formulation (BI 58 EC) were used as test material in a teratogenicity test in chicken after administration as a single compounds or in combination. The incubated chicken eggs were directly exposed to the applied test materials with injection into the air-chamber in a volume of 0.1 mL/egg before the starting of incubation. Applied concentration of Cd-sulphate was 0.01% and the concentration of pesticide was 0.1%. Evaluation was done on day 19. In test of individual toxicity after injection on day 0 of incubation Cd-sulphate did not cause a significant reduction in body mass of embryos. The rate of embryonic mortality was 26%. After the administration of dimethoate containing insecticide formulation on day 0 of incubation no decrease occurred in embryonic body mass. The rate of embryonic mortality was 31%. The developmental anomalies observed in the different treatment groups occurred sporadically. The simultaneous administration of Cd-sulphate and the dimethoate containing insecticide formulation on day 0 of incubation resulted in expressed embryonic mortality. The rate of embryonic mortality was 93%. In summary, it can be established that the simultaneous administration of Cd-sulphate and the dimethoate containing insecticide formulation on day 0 in studies of chemical interaction exerted an adverse effect on embryonic mortality.|Cadmium is a well-known animal teratogen. Caffeine is an alkaloid widely consumed by humans. Interactions between teratogens and nonteratogenic doses of other agents are becoming widely studied, as they may shed light on understanding mechanisms of teratogenicity or possible prevention of teratogenic effects. C57BL/6JBK mice were injected intraperitoneally (ip) with cadmium sulfate (Cd) at 0, 1.00 (LDCd), 2.50 (MDCd), or 5.00 (HDCd) mg/kg, immediately followed by subcutaneous (sc) administration of 0 or 50 mg/kg caffeine (CAFF) on gestation day (GD) 9. Fetuses were examined on GD 18 for ectrodactyly and other gross morphological malformations. Amelioration of cadmium-induced forelimb ectrodactyly by CAFF was seen in both the high-dose cadmium (HDCd = 65.4%, HDCd+CAFF = 39.2%) and medium-dose cadmium (MDCd = 46.2%, MDCd+ CAFF = 20.8%) treatment groups (P < 0.025). Bilateral expression of ectrodactyly was also decreased in the presence of caffeine. A statistically significant reduction in Cd-induced abnormalities, including: eye, abdominal, and other skeletal defects, was not seen with caffeine addition, although they did trend downward in the caffeine-supplemented groups. Litter size, fetal weight, fetal mortality, and dam weight also were not affected by co-treatment with caffeine.This study provides evidence that a subteratogenic dose of caffeine can ameliorate cadmium-induced forelimb ectrodactyly in the Cd-sensitive C57BL/6J inbred mouse strain.|Zinc (Zn) and selenium (Se) exert regulatory activities on immune functions, while cadmium (Cd) is an immunotoxic agent. The object of this study was to detect effects of 1x10-4, 1x10-5, and 1x10-6 M Cd sulphate, Zn sulphate, and sodium selenite, and their combinations on human peripheral blood mononuclear cell (PBMC) proliferation and IFN-gamma and TNF-alpha production. Only 1x10-5 M Zn sulphate significantly enhanced spontaneous PBMC proliferation, which was unaffected by the other salts. At 1x10-4 and 1x10-5 M, Cd sulphate exerted a dose-response inhibitory action on phytohemagglutinin- (PHA-) stimulated PBMC proliferation and cytokine release, while 1x10-4 M and 1x10-5 M Zn sulphate and 1x10-5 M sodium selenite induced a stimulatory effect on both proliferation and cytokine release; 1x10-4 M sodium selenite enhanced only the PBMC proliferation; at 1x10-6 M, none of the salts changed the PHA-stimulated immune activity. Moreover, 1x10-4 and 1x10-5 M Zn and 10(-5) M Se strongly upregulated IFN-gamma (a Th1 cytokine) release, even in presence of 10(-5) M Cd, and reduced the inhibitory effects of Cd on PBMC proliferation and TNF-alpha release. This study confirms that Zn and Se both strongly enhance cytokine release induced by mitogenic stimulation, showing also that Zn acts with a broader range of concentrations than Se. This suggests that dietary excess of Se may not have beneficial effects.|Cadmium (Cd) is a well-known nephrotoxicant inducing kidney damage via oxidative stress. Since kidney is the critical target organ of Cd toxicity, this study was designed to evaluate the protective effects of onion (Allium cepa L.) and garlic (Allium sativum L.) aqueous extracts on Cd-induced renal oxidative stress in male Wistar rats. The control group received double distilled water alone and Cd group was challenged with 3CdSO4 x 8H2O (as Cd) (1.5 mg/100 g bw/day per oral) alone. Extract-treated groups were pre-treated with varied doses (0.5 mL and 1.0 mL/100 g bw/day per oral) of onion and/or garlic extract for 1 week after which they were co-treated with Cd (1.5 mg/100 g bw/day per oral) for 3 weeks. The results showed that the levels of renal lipid peroxidation (LPO) and glutathione-S transferase (GST) were significantly (P < 0.001) increased in rats that received Cd alone relative to the control group. More so, the levels of renal glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and Na(+)/K(+)-ATPase were significantly (P < 0.001) decreased in rats that received Cd alone. Treatment of Cd-intoxicated rats with varied doses of onion and/or garlic extract significantly (P < 0.05) restored the alterations in these parameters relative to the group that received Cd alone. While treatment with high dose of onion extract exerted a significant dose-dependent restoration of these parameters, treatment with high dose of garlic elicited a pro-oxidant effect, relative to their respective low dose. Our study suggests that onion and garlic extracts may exert their protective effects via reduction in LPO and enhanced antioxidant defense. These extracts may, therefore, be useful nutritional option in alleviating Cd-induced renal damage.|For more Interactions (Complete) data for CADMIUM SULFATE (15 total), please visit the HSDB record page.

LD50 Rat oral 280 mg/kg|LD50 Mouse oral 88 mg/kg|LD50 Mouse ip 12,760 ug/kg

/BIRDS and MAMMALS/ The use of pesticides in field application involves the risk of poisoning wild animals. The reproduction period of pheasant takes place at the same time as the spraying time of pesticides, which justifies, that we evaluate in a point of the ecotoxicologic view the influence of the pesticide on progressive avian embryo. The most frequent technical way is injecting the exam stuffs to the some part of the embryonated eggs under the bird teratological trials. The advantage of this method is that it can be injected in a correct measured dose into the optional part of eggs. The disadvantage of this method is that it can't model properly the influence on the environment. If adverse effect of the embraced chemical substance on the embryo is experienced under the study, it will be necessary to use an immersion treatment. This procedure shows only the possible indirect influence of the pesticide on the embryo but it can suitably model its influence in plant protection practice. Treatment was done on day 12 of incubation. Applied concentration of heavy element (Cd sulphate) was 0.01% and the concentration of pesticide (Dithane M-45) was 0.2%. Evaluation was done on day 19 of incubation. Injection treatment: the simultaneous administration of Cd sulphate and the 80% mancozeb containing fungicide formulation on day 12 of incubation did not result in a significant decrease in the average body weight of embryos compared to neither the control nor the pesticide individually treated group. At the same time the body weight of embryos significantly decreased because of combined administration as compared to the Cd sulphate treated group. The embryo mortality and the incidence of developmental anomalies markedly increased after the simultaneous administration. Immersion treatment: the combined administration of Cd sulphate and the mancozeb containing fungicide formulation on day 12 of incubation did not result in a significant decrease in the average body mass of embryos compared to neither the control nor the individually treated groups. The number of embryo mortality was very high after the simultaneous administration. The incidence of developmental anomalies was sporadic.|/AQUATIC SPECIES/ ...The purpose of this study was to determine the size distribution of CdTe in freshwater, bioavailability and potential toxic effects of cadmium telluride quantum dots (CdTe QD) to the freshwater mussel Elliptio complanata. Mussels were exposed to increasing concentrations (0 to 8 mg Cd /per/ L) of CdTe and 0.5 mg/L CdSO4 for 24 hr at 15 degrees C to examine the initial uptake and toxic effects of Cd from CdTe QDs and dissolved CdSO4. After the exposure period, Cd bioaccumulation in the gills, digestive gland and gonad tissues and metallothionein (MT) levels were determined. The results revealed that about 80% of Cd was retained by a 450 nm pore filter (aggregates) and that 14% of the Cd was in the dissolved phase (i.e., eluted through a 1 kDa ultrafiltration membrane) which suggested that uncoated CdTe QDs were not stable in freshwater. In mussels, Cd was accumulated principally by the gills and digestive gland and the bioaccumulation factors of Cd from CdTe were similar to that of dissolved Cd. Indeed, tissue-levels of Cd were below the proportion of dissolved Cd from CdTe which suggests that Cd rather comes from the dissociation of Cd from the ingested QDs than from the internalization of the QDs in mussel tissues. The levels of MT were induced in both the digestive gland and gonad but were readily decreased in the gills by both CdTe and CdSO4. The observed decrease in the metallic form of MT might result from the oxidative stress by CdTe and dissolved Cd. In conclusion, uncoated CdTe QD in freshwater leads to aggregates and a dissolved component of Cd where the latter explained the contribution of the observed accumulation pattern in mussel tissues and effects on MT levels in mussels.|/AQUATIC SPECIES/ Understanding the effects of chemical toxicants on energetic processes is an important aspect of ecotoxicology. However, the influence of toxicant concentration and time of exposure on metabolism in aquatic organisms is still poorly understood. The purpose of this investigation was to determine the influence of increasing levels of three stressors (Cu, Cd, percent salinity) and exposure time (24 hr and 96 hr) on the metabolic rate of fathead minnows (Pimephales promelas). In all 24-hr exposures, there existed a threshold concentration, above which metabolic rate decreased significantly compared to the control and lower concentrations. In contrast, the metabolic rate of fish exposed for 96 hr increased significantly in all concentrations compared to fish from the control. We suggest fathead minnows exhibit a consistent pattern of metabolic response to stressors, regardless of the physiological mechanisms involved, and that this response differs as a function of time of exposure.|/AQUATIC SPECIES/ The purpose of this study was to examine the toxic effects of cadmium-telluride (CdTe) quantum dots on freshwater mussels. Elliption complanata mussels were exposed to increasing concentrations of CdTe (0, 1.6, 4 and 8 mg/L) and cadmium sulfate (CdSO4, 0.5mg/L) for 24hr at 15 degrees C. After the exposure period, they were removed for assessments of immunocompetence, oxidative stress (lipid peroxidation) and genotoxicity (DNA strand breaks). Preliminary experiments revealed that CdTe dissolved in aquarium water tended to aggregate in the particulate phase (85%) while 15% of CdTe was found in the dissolved phase. Immunotoxicity was characterized by a significant decrease in the number of hemocytes capable of ingesting fluorescent beads, and hemocyte viability. The cytotoxic capacity of hemocytes to lyse mammalian K-562 cells was significantly increased, but the number of circulating hemocytes remained unchanged. Lipid peroxidation was significantly increased at a threshold concentration of 5.6 mg/L in gills and significantly reduced in digestive glands at a threshold concentration <1.6 mg/L CdTe. The levels of DNA strand breaks were significantly reduced in gills at <1.6 mg/L CdTe. In digestive glands, a transient but marginal increase in DNA strand breaks occurred at the lowest concentration and dropped significantly at the higher concentrations. A multivariate analysis revealed that the various response patterns differed based on the concentration of CdTe, thus permitting the identification of biomarkers associated with the form (colloidal vs. molecular) of cadmium.|For more Ecotoxicity Excerpts (Complete) data for CADMIUM SULFATE (11 total), please visit the HSDB record page.

... CADMIUM SULFATE CAN ALSO BE FOUND IN ATMOSPHERIC EMISSIONS FROM THERMAL PROCESSES INVOLVING CADMIUM. ... /IT/ MAY APPEAR IN SURFACE WATERS AS RESULT OF RUN-OFF FROM INDUSTRIAL PROCESSES.

Corbicula fluminea (Asiatic clam) exposed to cadmium sulfate for 28 days exhibited a bioconcentration factor of 1752-3770. /Whole body/|Daphnia magna (cladoceran) exposed to cadmium sulfate for 2-4 days exhibited a bioconcentration factor of 320. /Whole body/|Daphnia magna (cladoceran) exposed to cadmium sulfate for 7 days exhibited a bioconcentration factor of 484. /Whole body/

IN RABBITS GIVEN 60 DAILY SC INJECTIONS OF CADMIUM SULFATE, ONLY ABOUT 1% OF DOSE WAS EXCRETED IN URINE EACH DAY.|ABOUT 20% OF IV DOSE IN RATS WAS EXCRETED VIA FECES IN 72 HR & LITTLE ... (115)CADMIUM WAS FOUND IN URINE; DISTRIBUTION IN LIVER ... AS SULFATE WAS UNIFORM, WHEREAS IN KIDNEY THE CORTEX SHOWED HIGH ACCUM & MEDULLA CONTENT WAS LOW. PANCREAS ACCUMULATED LARGE AMT IN UNIFORM DISTRIBUTION.|NEARLY 70% OF (109)CD-LABELED CADMIUM SULFATE WAS FOUND IN LIVER 20 DAYS AFTER IP ADMIN TO RATS. WHEN ADMIN SMALL REPEATED DAILY DOSES, LIVER ACCUM, RATHER THAN RENEW, ITS CADMIUM SUPPLY. BILE WAS ACTUALLY INSTRUMENTAL IN REABSORPTION OF CADMIUM INTO INTESTINE.|WHETHER CADMIUM SULFATE WAS INJECTED SC, IP OR IM TO RATS, THE AMT OF CADMIUM EXCRETED INTO URINE WERE NEARLY SAME.|Copper and cadmium uptake and distribution in 2-week-old seedlings of stone pine (Pinus pinea L.), maritime pine (Pinus pinaster Ait.) and ash (Fraxinus angustifolia Vahl.) were investigated. Seedlings were grown in culture solution at increasing concentrations of CuSO4, (0.012-5 muM) and CdSO4 (0.0-5 muM). All species accumulated copper in a larger amount than cadmium. Translocation to the shoot was strongly restricted for both metals, though higher cadmium mobility within the plant could be evidenced. A strong relationship between root content and growth inhibition was detected in the roots in response to copper but not to cadmium treatments. Among species P. pinea seemed to be more tolerant to cadmium, whereas F. angustifolia was highly sensitive to both cadmium and copper. X-ray microanalysis of root tip sections showed that copper and cadmium only accumulated in the root tips of F. angustifolia, copper mostly in the cell walls of the cortex layer, cadmium in the inner compartments of the cortex cells. It is suggested that in the two Pinus species the well developed root cap plays a protecting role against metal uptake at the root-tip zone.

Cadmium sulfate, reagent grade has the following impurities: insoluble matter: 0.005%; substances not precipitated by hydrogen sulfide as SO4: 0.15%; chloride: 0.001%; nitrate and nitrite (NO3): 0.003%; copper: 0.002%; iron: 0.001%; lead: 0.003%; zinc: 0.10%; arsenic: 2 ppm. /Cadmium sulfate, anhydrous/|Cadmium sulfate, reagent grade has the following impurities: insoluble matter: 0.005%; substances not precipitated by hydrogen sulfide as SO4: 0.1%; chloride: 0.001%; nitrate and nitrite as NO3: 0.003%; copper: 0.002%; iron: 0.001%; lead: 0.001% 0.001%; zinc: 0.1%; arsenic: 1 ppm. /Cadmium sulfate 8/3 hydrate (3CdSO4.8H2O)/|Cadmium sulfate (as 3CdSO4.8H2O) ... impurities (%): CI, 0.001; NO3, 0.003; Cu, 0.002; Fe, 0.001; Pb, 0.003; Zn, 0.1; and As, 1-2 ppm

Inhalation may cause dryness of throat, coughing, constriction in chest, and headache. Ingestion may cause salivation, vomiting, abdominal pains, or diarrhea. Contact with eyes causes irritation. (USCG, 1999)|Carcinogens, Mutagens

INHALATION: remove victim from exposure and consult a physician. INGESTION: induce vomiting, then allay irritation with milk or egg whites given at frequent intervals; perform gastric lavage; seek medical attention. EYES: flush with water for at least 10 min.; consult a physician. SKIN: wash with soap and water. (USCG, 1999)

Fresh air, rest. Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Cadmium and Related Compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Cadmium and Related Compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... .... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Cadmium and Related Compounds/

/CASE REPORTS/ .../described is/ the case of a female denture wearer who was referred ... due to burning of the lips and tongue but with no visible oral lesions. Her biochemical data, complete blood cell count, sedimentation rate, thyroid and sex hormones were normal. Tongue culture was negative. Patch tests, performed with a panel of 20 potential denture allergens, gave positive results (+++) only to a 2% petrolatum cadmium sulfate, which was present in the denture. Removal of the denture led to the clearing up of oral symptoms in 3 days. In light of these findings, carrying out patch tests with the allergens related to denture materials should be considered in these cases.|/GENOTOXICITY/ Cadmium (Cd) is a hazardous heavy metal affecting many cellular functions, but little is known on cellular defense mechanisms. This article describes a study of a Cd-induced gene expression profile. Messenger RNA was prepared from HeLa cells exposed to a non-lethal dose of CdSO4, and analysed by the use of an array consisting of 7075 human cDNAs. Many stress response genes including those coding for metallothioneins and heat shock proteins were observed to be induced by Cd. The cellular metabolism inclined toward the synthesis of cysteine and glutathione after Cd exposure. Anti-oxidant genes also appeared to be induced to protect cell components and to quench reactive oxygen species. Ubiquitin pathway was activated as well probably to degrade proteins which might not be renatured. These data suggest that human cells mobilize every genomic resource to overcome cytotoxicity caused by Cd.|/GENOTOXICITY/ Six chemicals, known to induce lung tumors in rats, were examined for their ability to induce DNA fragmentation in primary cultures of rat and human lung cells, and in the lung of intact rats. Significant dose-dependent increases in the frequency of DNA single-strand breaks and alkali-labile sites, as measured by the single-cell gel electrophoresis (Comet) assay, were obtained in primary lung cells from male rats with the following, minimally toxic, concentrations of the six test compounds: N-nitrosodimethylamine (NDMA; 2.5-10 mM), hydrazine (HZ; 0.5-4 mM), cadmium sulfate (CD; 31.2 and 62.5 uM), 4,4'-methylene bis (2-chloroaniline) (MOCA; 31.2-125 uM), isobutyl nitrite (IBN; 7.8-31.2 uM) and tetranitromethane (TNM; 1.9-15.6 uM). Similar degrees of DNA fragmentation were obtained in primary human lung cells; however, due to inter-donor differences, the minimum effective concentrations were in some donors lower and in others higher than in rats, and IBN induced DNA damage only in one of three donors. The DNA-damaging potency of HZ was higher in rats than in humans, and the opposite was true for MOCA. In agreement with these findings, statistically significant increases in the average frequency of DNA breaks were obtained in the lung of rats given a single oral dose (1/2 LD50) of the six test compounds. These findings give evidence that genotoxic lung carcinogens may be identified by use of the DNA fragmentation/Comet assay on rat lung cells as targets cells, and show that the six compounds tested produce in primary cultures of lung cells from human donors DNA-damaging effects substantially similar to those observed in rats.|/GENOTOXICITY/ Cadmium (Cd) is a toxic heavy metal of continuing occupational and environmental concern with a wide variety of adverse effects. Several studies have shown that cadmium produces DNA strand breaks, DNA-protein cross-links, oxidative DNA damage, chromosomal aberrations, dysregulation of gene expression resulting in enhanced proliferation, depressed apoptosis and/or altered DNA repair. This study was undertaken to investigate the ability of cadmium chloride (CdCl2) and cadmium sulfate (CdSO4) to induce point mutations in codon 12 of the K-ras protooncogene assessed by polymerase chain reaction-single strand conformation polymorphisms (PCR-SSCP) and /restriction fragment length polymorphisms/ RFLP-enriched PCR methods. Also their genotoxic effects were analyzed by the comet assay and sister chromatid exchanges test. The human lung fibroblast cell line MRC-5 was used for the experiments. Sister chromatid exchanges assay (SCEs) frequencies were significantly increased in cells exposed to cadmium salts in relation to controls (p<0.001). Despite the slow increment observed in the three comet parameters considered when cells were treated with cadmium chloride, significant differences between groups were only found in the variable comet moment (CM) (p<0.005). On the other hand, when cells were exposed to cadmium sulphate, the Kruskal-Wallis test showed highly significant differences between groups for migration, tail moment and comet moment parameters (p<0.001). Nevertheless, a null or weak point mutation induction in K-ras protooncogene was detected using polymerase chain reaction-low ionic strength-single strand conformation polymorphisms (PCR-LIS-SSCP) and RFLP-enriched PCR methods when cells were treated with cadmium salts. Thus, inorganic cadmium produces genotoxicity in human lung fibroblast MRC-5 cells, in the absence of significant point mutation of the K-ras gene.|For more Human Toxicity Excerpts (Complete) data for CADMIUM SULFATE (10 total), please visit the HSDB record page.

cadmium sulfate

The substance can be absorbed into the body by inhalation and by ingestion.

Cough.

Redness.

Redness.

Reagent grade: 99.0% min|Reagent grade: 99.0-102.0% /Cadmium sulfate 8/3 hydrate (3CdSO4.8H2O)/|Cadmium sulfate (as 3CdSO4.8H2O) - purities: 98-99.999%; American Chemical Society reagent grade, 98-99.0%

Sulfuric acid, cadmium salt (1:1): ACTIVE|COMMERCIAL GRADE CADMIUM SULFATE REPORTEDLY CONTAINS ABOUT 49.5% CADMIUM; THEORETICAL CADMIUM CONTENT OF CADMIUM SULFATE IS 53.5%.|CdSO4.8/3H2O is the normal commercial form of cadmium sulfate and is made by dissolving cadmium metal, oxide, sulfide, hydroxide, or carbonate in sulfuric acid.|Cadmium sulfate is the most common cadmium salt|Cadmium forms a number of salts, of which the sulfate is the most common; the sulfide is used as a yellow pigment

Health Hazards -> Carcinogens, Mutagens