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GZD 824

GZD 824 structure

CAS No:
1257628-77-5
Formula:
C29H27F3N6O
Chemical Name:
GZD 824
Synonyms:
4-Methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide;3-(2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide;GZD8824;GZD-824 Free;GZD 824;GZD824;GZD-824
Categories:
Biochemical Engineering > Inhibitors

Description

HQP1351 is under investigation in clinical trial NCT03883100 (A Pivotal Study of HQP1351 in Patients of Chronic Myeloid Leukemia in Accelerated Phase With T315I Mutation).|Olverembatinib is an orally bioavailable inhibitor of a variety of kinases, including the Bcr-Abl tyrosine kinase, the mast/stem cell growth factor receptor Kit (c-Kit), the serine/threonine protein kinase Akt (protein kinase B), and the extracellular signal-regulated kinase (ERK) with antineoplastic activity. Upon administration,olverembatinib targets, binds to and inhibits the kinase activities of Bcr-Abl, AKT, c-Kit and ERK. This inhibits their mediated signaling pathways and inhibits proliferation of tumor cells in which these kinases are overexpressed and/or mutated. Bcr-Abl, c-Kit, AKT and ERK play key roles in the proliferation, differentiation and survival of tumor cells.

GZD 824 Basic Attributes

Molecular Weight：

532.5594896

Exact Mass：

532.22

UNII：

KV1M7Q3CBP

NCI Thesaurus Code：

C165549

Characteristics

PSA：

77.2

XLogP3：

4.6

Density：

1.39±0.1 g/cm3(Predicted)

Boiling Point：

630.4±55.0 °C(Predicted)

Drug Information

MeSH Entry Terms：

3-((1H-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Computed Properties

Molecular Weight:532.6
XLogP3:4.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:532.21984399
Monoisotopic Mass:532.21984399
Topological Polar Surface Area:77.2
Heavy Atom Count:39
Complexity:910
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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GZD-824

CAS No.: 1257628-77-5

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