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K 02288

K 02288 structure

CAS No:
1431985-92-0
Formula:
C20H20N2O4
Chemical Name:
K 02288
Synonyms:
K 02288;3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;K 02288 Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-;K022883-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;LM-3151K02288;K 02288(K 02288a);K 02288a
Categories:
Biochemical Engineering > Inhibitors

Description

K02288 is a potent inhibitor of ALK, and inhibits ALK1/2/3/6 with IC50s of 1.8/1.1/34.4/6.3 nM; K02288 is less potent against ALK4/5, with IC50s of 302 nM and 321 nM.

K 02288 Basic Attributes

Molecular Weight：

352.39

Exact Mass：

352.142303

Characteristics

PSA：

86.8

XLogP3：

3.3

Density：

1.232±0.06 g/cm3(Predicted)

Boiling Point：

522.2±50.0 °C(Predicted)

Flash Point：

269.6±30.1 °C

Refractive Index：

1.614

Safety Information

Packing level：

Ⅲ

Transport codes：

UN 2811 6.1 / PGIII

hazard class code：

6.1

Precautionary statement(s)：

P280-P301 + P310 + P330-P305 + P351 + P338 + P310

Hazard Statements：

H301-H318