Epiberberine
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Epiberberine
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CAS No:
6873-09-2
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Formula:
C20H18NO4
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Chemical Name:
Epiberberine
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Synonyms:
Benzo[a]-1,3-benzodioxolo[4,5-g]quinolizinium,11,12-dihydro-8,9-dimethoxy-;Berbinium,7,8,13,13a-tetradehydro-2,3-dimethoxy-9,10-(methylenedioxy)-;11,12-Dihydro-8,9-dimethoxybenzo[a]-1,3-benzodioxolo[4,5-g]quinolizinium;Epiberberine;Dehydrosinactine
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CAS No:
Description
Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways[2]. Epiberbe
Computed Properties
Molecular Weight:336.4
XLogP3:3.6
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:336.12358306
Monoisotopic Mass:336.12358306
Topological Polar Surface Area:40.8
Heavy Atom Count:25
Formal Charge:1
Complexity:488
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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