ETHYL 4-ETHOXYPHENYLACETATE

The preparation method can use phenylethyl ether as the raw material, add hydrogen chloride to saturated hydrochloric acid and benzene solution, then add cold aqueous formaldehyde solution, continue to pass hydrogen chloride, the mixture is stirred at room temperature for 2h, the phenylethyl ether is chloromethylated, the reaction liquid Separate the water layer and the benzene layer, wash with NaHCO3 solution to neutrality, dry, and evaporate the benzene under reduced pressure to obtain colorless and transparent o-ethoxy benzyl chloride. The mixture is an unstable compound and cannot be separated. Further cyanidation is carried out. In the aqueous sodium cyanide solution, acetone and tetrabutylammonium bromide are added as phase transfer catalysts, and then o- and p-ethoxybenzyl chloride are added. Stir vigorously at 56°C for 6h, cool and add water, separate the water layer, wash the oil layer until it is neutral, it is an orange liquid, which is o- and p-ethoxybenzyl cyanide, fractionate under reduced pressure to obtain p-ethoxy cyanide Benzyl. Add p-ethoxybenzyl cyanide to the ethylene glycol solution containing potassium hydroxide, react with heating and stirring, cool to room temperature, acidify, add water and benzene, extract p-ethoxyphenylacetic acid with benzene, and then distill off benzene. To obtain p-ethoxyphenylacetic acid, further esterify with absolute ethanol in the presence of an acid catalyst to obtain p-ethoxyphenylacetic acid ethyl acetate. You can also use p-methylphenol as a raw material, first etherify with diethyl sulfate to produce p-methyl phenyl ethyl ether, further chlorinate to obtain p-ethoxybenzyl chloride, and then cyanide with sodium cyanide in the presence of a phase transfer catalyst P-ethoxybenzyl cyanide is hydrolyzed to generate p-ethoxyphenylacetic acid, and esterified to obtain p-ethoxyphenyl ethyl acetate. It is also possible to use p-ethoxyacetophenone to react with sodium hydroxide in the presence of piperazine sulfide at a reaction temperature of 135～140℃, reaction for 20h, after the reaction is completed, cooling post-treatment, and p-ethoxyphenylacetic acid can also be prepared. Further prepare ethyl p-ethoxyphenylacetate.

Ethyl ethoxyphenate is an intermediate in the preparation of cypermethrin.

Molecular Weight:208.25
XLogP3:2.6
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:208.109944368
Monoisotopic Mass:208.109944368
Topological Polar Surface Area:35.5
Heavy Atom Count:15
Complexity:183
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes