Ryanodine
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Ryanodine
structure -
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CAS No:
15662-33-6
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Formula:
C25H35NO9
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Chemical Name:
Ryanodine
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Synonyms:
1H-Pyrrole-2-carboxylic acid,(3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester;Ryanodine;Ryanodol,3-(1H-pyrrole-2-carboxylate);Ryanex;Ryania;Ryanicide;Ryanodin;(+)-Ryanodine;Ryania (pesticide);1H-Pyrrole-2-carboxylic acid,dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester,[3S-(3α,4β,4aS*,6α,6aα,7α,8β,8aα,8bβ,9β,9aα)]-;1361-01-9;1580-06-9;8047-13-0;15800-60-9;25800-57-1
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CAS No:
Description
Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.
A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.
Characteristics
172.70000
3.86
white to beige
1.6±0.1 g/cm3
219-220 °C
714.2±60.0 °C at 760 mmHg
385.7±32.9 °C
1.685
DMSO: soluble 10mg/mL, clear
-20°C
Oral-Rat LD50: 750 mg/kg; Oral-Mouse LD50: 650 mg/kg
Combustion produces toxic nitrogen oxide gas
D25 +26° (methanol)
Safety Information
UN30779/PG3
21/22-50/53
36/37-60-61
VM4025000
Xn,N
The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials
P273-P280-P501
H302 + H312-H410
|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P280, P301+P312, P302+P352, P312, P322, P330, P363, P391, and P501|H302+H312 (19.49%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]|Aggregated GHS information provided by 195 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Computed Properties
Molecular Weight:493.5
XLogP3:-0.5
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:493.23118169
Monoisotopic Mass:493.23118169
Topological Polar Surface Area:173
Heavy Atom Count:35
Complexity:1010
Undefined Atom Stereocenter Count:11
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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