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Mitiglinide calcium

Mitiglinide calcium structure

CAS No:
145525-41-3
Formula:
C19H25NO3.¹/2Ca
Chemical Name:
Mitiglinide calcium
Synonyms:
2H-Isoindole-2-butanoic acid,octahydro-γ-oxo-α-(phenylmethyl)-,calcium salt (2:1),(αS,3aR,7aS)-;2H-Isoindole-2-butanoic acid,octahydro-γ-oxo-α-(phenylmethyl)-,calcium salt,[2(S)-cis]-;2H-Isoindole-2-butanoic acid,octahydro-γ-oxo-α-(phenylmethyl)-,calcium salt,(αS,3aR,7aS)-;KAD 1229;S 21403;(S)-2-Benzyl-4-oxo-4-(cis-perhydroisoindol-2-yl)butyric acid calcium salt;Glufast;Mitiglinide calcium;1536121-38-6
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Mitiglinide is the calcium salt form of Mitiglinide, which is a drug for the treatment of type II diabetes. It belongs to the meglitinide class blood glucose-lowering drug. Its mechanism of action is through stimulating the insulin secretion through closing the ATP-sensitive potassium channels in the pancreatic beta-cells. This process leads to depolarization, further stimulating the influx of calcium through the voltage-gated calcium channels. The high intracellular calcium level results in th

Mitiglinide calcium Basic Attributes

Molecular Weight：

668.88

Exact Mass：

668.3138281 g/mol

EC Number：

1308068-626-2

DSSTox ID：

DTXSID90872410

HScode：

2942000000

Characteristics

PSA：

102.45000

XLogP3：

5.59450

Appearance：

white to beige

Density：

1.175

Melting Point：

175-183 °C @ Solvent: Ethanol

Boiling Point：

519.6°C at 760 mmHg

Flash Point：

268ºC

Water Solubility：

DMSO: ≥10mg/mL at warmed to 60°C

Storage Conditions：

room temp

Vapor Pressure：

1.27E-11mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

Marks：

GHS Classification：

|Warning|H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]|P260, P314, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Mitiglinide calcium Use and Manufacturing

Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells

Computed Properties

Molecular Weight:668.9
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:668.3138281
Monoisotopic Mass:668.3138281
Topological Polar Surface Area:121
Heavy Atom Count:47
Complexity:411
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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Mitiglinide calcium

CAS No.: 145525-41-3

Grade: industrial Grade

Content: 98%

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