2-Bromo-3-methoxy-6-nitropyridine

Off-White Solid

2-Amino-5.6-dimethoxypyridine(a) 2-Bromo-3 -methoxy-6-nitropyridine2-Bromo-3-methoxypyridine (4.45 g, 23.7 mmol) was added to a mixture of fuming HNO2-Bromo-3-methoxypyridine (4.45 g, 23.7 mmol) was added to a mixture of fuming HNOTo a solution of 2-bromo-3-methoxypyridine (0.1 g) in conc. sulfuric acid (2 mL) wasadded nitric acid (0.1 g). The mixture was stirred at 55°C for 3 hours. After cooling, the mixturewas poured into water (10 mL). The mixture was filtered. The solid was washed with water, and then redissolved in DCM. The solution was dried over Na2SO4 and concentrated in vacuo to afford 2-bromo-3-methoxy-6-nitropyridine (60 mg). MS(ES) m/z 233 (MH).2-Amino-5.6-dimethoxypyridine(a) 2-Bromo-3 -methoxy-6-nitropyridine2-Bromo-3-methoxypyridine (4.45 g, 23.7 mmol) was added to a mixture of fuming HNO2-Bromo-3-methoxypyridine (4.45 g, 23.7 mmol) was added to a mixture of fuming HNOTo a solution of 2-bromo-3-methoxypyridine (0.1 g) in conc. sulfuric acid (2 mL) wasadded nitric acid (0.1 g). The mixture was stirred at 55°C for 3 hours. After cooling, the mixturewas poured into water (10 mL). The mixture was filtered. The solid was washed with water, and then redissolved in DCM. The solution was dried over Na2SO4 and concentrated in vacuo to afford 2-bromo-3-methoxy-6-nitropyridine (60 mg). MS(ES) m/z 233 (MH).

Molecular Weight:233.02
XLogP3:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:231.94835
Monoisotopic Mass:231.94835
Topological Polar Surface Area:67.9
Heavy Atom Count:12
Complexity:173
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes