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2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid

2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid structure

CAS No:
223488-57-1
Formula:
C25H28N2O5S
Chemical Name:
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid
Synonyms:
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid;CP-533536;Evatanepag
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Evatanepag (CP-533536) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.IC50 value: 0.3 nM (EC50)Target PGE2in vitro: CP-533536 is a potent and selective EP2agonist. CP-533536 demonstrates the ability to heal fractures when administered locally as a single dose in rat models of fracture healing. CP-533536 demonstrates excellent in vitro potency against EP2 and selectivity against a broad panel of other targets.

Evatanepag is a monocarboxylic acid.|Evatanepag has been used in trials studying the treatment of Tibial Fractures.

2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Basic Attributes

Molecular Weight：

468.56

Exact Mass：

468.171906

UNII：

L266R6E31E

Characteristics

PSA：

105.18000

XLogP3：

4.78

Density：

1.3±0.1 g/cm3

Boiling Point：

660.2±65.0 °C at 760 mmHg

Flash Point：

353.0±34.3 °C

Refractive Index：

1.600

Drug Information

MeSH Entry Terms：

(3-((4-tert-butylbenzyl)-(pyridine-3-sulfonylamino)methyl)phenoxy)acetic acid

Computed Properties

Molecular Weight:468.6
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:10
Exact Mass:468.17189317
Monoisotopic Mass:468.17189317
Topological Polar Surface Area:105
Heavy Atom Count:33
Complexity:722
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Latest News
Learn More Other Chemicals

2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid

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