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2,5-Dibromo-3-nitropyridine

2,5-Dibromo-3-nitropyridine structure

CAS No:
15862-37-0
Formula:
C5H2Br2N2O2
Chemical Name:
2,5-Dibromo-3-nitropyridine
Synonyms:
Pyridine,2,5-dibromo-3-nitro-;2,5-Dibromo-3-nitropyridine;NSC 170627
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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2,5-Dibromo-3-nitropyridine Basic Attributes

Molecular Weight：

281.89

Exact Mass：

281.89

EC Number：

-0

NSC Number：

170627

DSSTox ID：

DTXSID20305387

HScode：

2933399090

Characteristics

PSA：

58.7

XLogP3：

2.4

Appearance：

Yellow Solid

Density：

2'+-.0.06 g/cm3(Predicted)

Melting Point：

97-98 °C

Boiling Point：

272.7±35.0 °C(Predicted)

Flash Point：

118.7±25.9 °C

Refractive Index：

1.650

Vapor Pressure：

0.00263mmHg at 25°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

safety instructions：

Marks：

Xi,T

Hazard note：

Irritant

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

2,5-Dibromo-3-nitropyridine Use and Manufacturing

Intermediate 12; N-[(R)-1-(5-Bromo-3-fluoro-pyridin-2-yl)-ethyl]-acetamide Step A: 2, 5-Dibromo-3-nitro-pyridine To a suspension 5-bromo-3-nitro-pyridin-2-ol (20 g, 91.32 mmol) in toluene (100 ml) was added DMF (0.7 ml, 9.13 mmol) and the mixture was heated to 90° C. (the reaction mixture was protected from light). A solution of POBrStep A: 2, 5-Dibromo-3-nitro-pyridineTo a suspension 5-bromo-3-nitro-pyridin-2-ol (20 g, 91.32 mmol) in toluene (100 ml) was added DMF (0.7 ml, 9.13 mmol) and the mixture was heated to 90°C (the reaction mixture was protected from light). A solution of POBrTo a solution of 5-Bromo-3-nitro-pyridin-2-ol (10.0 g, 45.66 mmol) in 70 ml of toluene and 7 ml of DMF was added PBr(1) Production of 2, 5-dibromo-3-nitropyridine: Hydrogen bromide (48 percent in HSynthesis Synthesis of N-ethyl-N-methyl-N'[2, 5-dimethyl-6-(4-t-butylphenyl)pyridin-3- y 1] formamidine (Compound No .11); (1); Bromine (68.81 mmol, 3.5 ml) was gradually added dropwise to an aqueous solution of 48percent hydrobromic acid (120 ml) of 2-amino-5-bromo-3-nitropyridine (22.93 mmol, 5.0 g) at 0°C, followed by stirring at the same temperature for 1 hour. An aqueous solution prepared by dissolving sodium nitrite (57.34 mmol, 4.0 g) in 60 ml of water was gradually added dropwise, followed by stirring at the same temperature for1.5 hours. To the resulting reaction mixture, 10 mol/liter sodium hydroxide aqueous solution was added on ice to neutralize, and an aqueous layer was extracted with ethyl acetate. An organic layer was washed with saturated saline, dried over anhydrous sodium sulfate, and filtered, followed by distilling away a solvent under reduced pressure. The resulting crude product was purified with column chromatography to obtain 2.24 g of 2, 5-dibromo-3-nitropyridine (yield 35percent). 4-{7- [(2, 3-dihydro [1 , 4] dioxino [2, 3-c] pyridin-7-ylmethyl)amino] -5- methyl-6-oxo-5, 6, 7, 8-tetrahydro-l, 5-naphthyridin-3-yl}-6-(methyloxy)pyrido[2, 3- b]pyrazin-3(4H)-one;

Computed Properties

Molecular Weight:281.89
XLogP3:2.4
Hydrogen Bond Acceptor Count:3
Exact Mass:281.84625
Monoisotopic Mass:279.84830
Topological Polar Surface Area:58.7
Heavy Atom Count:11
Complexity:161
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 15862-37-0

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Content: 99%

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2,5-Dibromo-3-nitropyridine

CAS No.: 15862-37-0

Content: 99.00%

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Guide of 2,5-Dibromo-3-nitropyridine

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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