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2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide

2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide structure

CAS No:
204205-90-3
Formula:
C22H16ClN3O2
Chemical Name:
2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
Synonyms:
Indibulin;2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide;lindiblin;Nascapine;ZIO 301;2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Indibulin (ZIO 301) , an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis[1].

Indibulin is a synthetic small molecule with antimitotic and potential antineoplastic activities. Indibulin binds to a site on tubulin that is different from taxane- or Vinca alkaloid-binding sites, destabilizing tubulin polymerization and inducing tumor cell cycle arrest and apoptosis. This agent has been shown to be active against multidrug-resistant (MDR) and taxane- resistant tumor cell lines.

2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide Basic Attributes

Molecular Weight：

389.83

Exact Mass：

389.093109

UNII：

80K4H2RB8P

DSSTox ID：

DTXSID70174368

NCI Thesaurus Code：

C2049

HScode：

2933399090

Characteristics

PSA：

XLogP3：

3.9

Density：

1.3±0.1 g/cm3

Refractive Index：

1.665

Storage Conditions：

Desiccate at -20°C

Drug Information

Drug Indication：

Investigated for use/treatment in solid tumors.

MeSH Entry Terms：

D 24851

Computed Properties

Molecular Weight:389.8
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:389.0931045
Monoisotopic Mass:389.0931045
Topological Polar Surface Area:64
Heavy Atom Count:28
Complexity:558
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 204205-90-3

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Guide of 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Recommended Suppliers
Latest News
Learn More Other Chemicals

2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide

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