BQ-123 SODIUM SALT
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BQ-123 SODIUM SALT
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CAS No:
136553-81-6
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Formula:
C31H42N6O7
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Chemical Name:
BQ-123 SODIUM SALT
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Synonyms:
BQ-123;BQ-123 SODIUM SALT;ETA-RECEPTOR ANTAGONIST;C(DTRP-DASP-PRO-DVAL-LEU);CYCLO (D-ALPHA-ASPARTYL-L-PROLYL-D-VALYL-L-LEUCYL-D-TRYPTOPHYL);CYCLO(D-ASP-PRO-D-VAL-LEU-D-TRP);CYCLO(D-ASP-PRO-D-VAL-LEU-DTRP NA);CYCLO(-D-TRP-D-ASP-PRO-D-VAL-LEU)
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CAS No:
Description
BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model.2) BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.3) The reference for animal injections is 6.7 mg/kg. 4) BQ-123 decreased IL-1β and TNFα in the placenta while also decreasing transcription of ET-1 in the uterus.
BQ 123 is a cyclic peptide.|BQ-123 has been investigated for the basic science and treatment of Coronary Artery Disease, Aorto-coronary Bypass Grafting, and ST-Elevation Myocardial Infarction.
Characteristics
190
2.2
lyophilized powder
1.33±0.1 g/cm3(Predicted)
1053.6±65.0 °C(Predicted)
591.0±34.3 °C
1.621
−20°C
Drug Information
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Compounds and drugs that bind to and inhibit or block the activation of ENDOTHELIN RECECPTORS. (See all compounds classified as Endothelin Receptor Antagonists.)
BQ 123
Computed Properties
Molecular Weight:610.7
XLogP3:2.2
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:610.31149770
Monoisotopic Mass:610.31149770
Topological Polar Surface Area:190
Heavy Atom Count:44
Complexity:1110
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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