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2,3-Dichloro-5-nitropyridine

2,3-Dichloro-5-nitropyridine structure

CAS No:
22353-40-8
Formula:
C5H2Cl2N2O2
Chemical Name:
2,3-Dichloro-5-nitropyridine
Synonyms:
Pyridine,2,3-dichloro-5-nitro-;2,3-Dichloro-5-nitropyridine
Categories:
Organic Chemistry > Organic Fluorine Compound

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Description

Light yellow Cryst

2,3-Dichloro-5-nitropyridine Basic Attributes

Molecular Weight：

192.99

Exact Mass：

192.99

DSSTox ID：

DTXSID90376741

HScode：

2933399090

Characteristics

PSA：

58.7

XLogP3：

2.3

Appearance：

Light yellow cryst.

Density：

1.6±0.1 g/cm3

Melting Point：

107-115 °C

Boiling Point：

254 °C

Flash Point：

>110°C

Refractive Index：

1.603

Safety Information

Packing level：

Ⅲ

Hazard category：

IRRITANT

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

36/37/38-43-41-37/38-25

safety instructions：

26-36/37/39-45-39

Marks：

Xi,T

Precautionary statement(s)：

P261-P280-P301 + P310-P305 + P351 + P338

Hazard Statements：

H301-H315-H318-H335

GHS Classification：

|Danger|H301 (97.5%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2,3-Dichloro-5-nitropyridine Use and Manufacturing

Quinoline (48.5 ml, 0.41 mol) was added to POCl3 (164.0 ml, 1.75 mol) at 0 C under nitrogen. To this stirred mixture, 2-hydroxy- 3-chloro-5-nitropyridine (204 mg, 1.17 mol) was added. The reaction mixturewas heated at 120 C for 2 h, cooled to 0 C followed by addition of ice-cold water. The precipitate obtained was filtered, washed thoroughly with water and dried to give 2, 3-dichloro-5- nitropyridine. Yield: 220 g, (97percent). M.P.: 53 C. 1H NMR (300 MHz, DMSO-d6): d 9.16 (d, 1H, J ¼ 2.4 Hz), 8.94 (d, 1H, J ¼ 2.4 Hz). 13C NMR (300 MHz, DMSO-d6): d 158.69, 137.36, 132.51, 130.13, 124.39. MS (ES): 193 (M þ 1).Quinoline (0.3 mL, 2.34 mmol) was added to POClQuinoline (0.3 mL, 2.34 mmol) was added to POClTo phosphorus oxychloride (37.4 mL, 0.4 mol) at 0° C. was added quinoline (23.6 mL, 0.2 mol), followed by 3-chloro-2-hydroxy-5-nitropyridine (70 g, 0.4 mol) from above.

Computed Properties

Molecular Weight:192.98
XLogP3:2.3
Hydrogen Bond Acceptor Count:3
Exact Mass:191.9493327
Monoisotopic Mass:191.9493327
Topological Polar Surface Area:58.7
Heavy Atom Count:11
Complexity:161
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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2,3-DICHLORO-5-NITROPYRIDINE 99% colorless liquid JINGHUI

CAS No.: 22353-40-8

Content: 99%

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Guide of 2,3-Dichloro-5-nitropyridine

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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2,3-Dichloro-5-nitropyridine

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