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Etifoxine

Etifoxine structure

CAS No:
21715-46-8
Formula:
C17H17ClN2O
Chemical Name:
Etifoxine
Synonyms:
4H-3,1-Benzoxazin-2-amine,6-chloro-N-ethyl-4-methyl-4-phenyl-;4H-3,1-Benzoxazine,6-chloro-2-(ethylamino)-4-methyl-4-phenyl-;6-Chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine;2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine;Etifoxine;Etifoxin;HOE 36-801
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Etifoxine(HOE 36-801) is potentiator of GABAA receptor function in cultured neurons. Etifoxine preferentially acts on β2 or β3 subunit-containing GABAA receptors. IC50 value:Target: GABAA receptorEtifoxine exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Etifoxine acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.

Etifoxine Basic Attributes

Molecular Weight：

300.787

Exact Mass：

300.78

HScode：

2934999090

Characteristics

PSA：

33.6

XLogP3：

3.78

Density：

1.2±0.1 g/cm3

Melting Point：

90-92 °C

Boiling Point：

421.2±55.0 °C at 760 mmHg

Flash Point：

208.5±31.5 °C

Refractive Index：

1.601

Vapor Pressure：

2.66E-07mmHg at 25°C

Toxicity：

Oral-Rat LD50: 1500 mg/kg; Oral-Mouse LD50: 1388 mg/kg

Flammability characteristics：

Flammable; decomposes toxic chloride and nitrogen oxide gas in the fire

Safety Information

Storage features：

Warehouse low temperature, ventilated, dry

Toxicity

Toxicity class：

moderately toxic