Magnesium stearate

632.31900

630.45700

209-150-3

70097M6I30

1403

DTXSID2027208

LUMPS|Fine, bulky, white powder|Soft, white, light powder

29157030

52.60000

12.50830

White powder

1.028 g/cm³

88 °C

359.4ºC at 760mmHg

162.4ºC

1.45 (25ºC)

H2O: Insoluble

Store at RT.

LD50 orally in Rabbit: > 2000 mg/kg

Odorless|Faint, characteristic odor

Tasteless

Decomposed by dilute acids

Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.

NONH for all modes of transport

-

R36/37/38

S26-S37/39

WI4390000

Xi

Stable. Incompatible with strong oxidizing agents.

P264, P305+P351+P338, P332+P313, P33, P313

H316

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Substance added directly to human food affirmed as generally recognized as safe (GRAS).|An ingredient whose use in food or food packaging is subject to a prior sanction or approval within the meaning of section 201(s)(4) of the Act is exempt from classification as a food additive. ... Substances classified as stabilizers, when migrating from food-packaging material shall include: magnesium stearate.

Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.

|Warning|H315 (39.3%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 541 companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H316: Causes mild skin irritation [Warning Skin corrosion/irritation]|P264, P305+P351+P338, P332+P313, and P337+P313

In case of fire in the surroundings, use appropriate extinguishing media.

Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.

A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.

PREVENT DISPERSION OF DUST!

Use local exhaust.

Protective gloves.

Wear safety spectacles.

contains small amounts of the oleate and 7% magnesium oxide. /technical grade/

Fresh air, rest.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/HUMAN EXPOSURE STUDIES/ ...DEATHS HAVE BEEN CAUSED BY ACCIDENTAL INHALATION OF THE /BABY DUSTING/ POWDER, /CONTAINING MAGNESIUM STEARATE/.|/HUMAN EXPOSURE STUDIES/ Slightly toxic by ingestion.

aluminum monostearate

The substance can be absorbed into the body by inhalation.

Cough.

MAGNESIUM STEARATE /IS/ COMPD OF MAGNESIUM WITH MIXTURE OF SOLID ORG ACIDS OBTAINED FROM FATS, & CONSISTS CHIEFLY OF VARIABLE PROPORTIONS OF MAGNESIUM STEARATE & MAGNESIUM PALMITATE. IT CONTAINS EQUIVALENT OF 6.8-8.0% OF MAGNESIUM OXIDE (40.30).|GRADES: TECHNICAL, USP FCC.|A TYPICAL DRY COMPRESSED ANTIPERSPIRANT STICK/CONTAINS/0.25 wt% MAGNESIUM STEARATE

All other chemical product and preparation manufacturing|Octadecanoic acid, magnesium salt (2:1): ACTIVE|The more important dusting powders include ... magnesium stearate, NF ...|Microspheres containing the mucoadhesive polymer chitosan hydrochloride, with matrix polymer Eudragit RS, pipemidic acid as a model drug and agglomeration preventing agent magnesium stearate were prepared by the solvent evaporation method. The amount of magnesium stearate was varied and the following methods were used for microsphere evaluation: sieve analysis, drug content and dissolution determination, scanning electron microscopy, x-ray diffractometry, DSC and FTIR spectroscopy. The results showed that average particle size decreased with increasing amount of magnesium stearate used for microsphere preparation. This is probably a consequence of stabilization of the emulsion droplets with magnesium stearate. Higher pipemidic acid content in the microspheres was observed in larger particle size fractions and when higher amounts of magnesium stearate were used. It was also found that these two parameters significantly influenced the dissolution rate. The important reason for the differences in drug content in microspheres of different particle sizes is the diffusion of pipemidic acid from the acetone droplets in liquid paraffin during the preparation procedure. The physical state of pipemidic acid changed from crystalline to mostly amorphous with its incorporation in microspheres, as shown by x-ray diffractometry and differential scanning calorimetry. No differences were observed in the physical state of pipemidic acid and in microsphere shape and surface between different size fractions of microspheres, prepared with different amounts of magnesium stearate. Additionally, no correlation between the physical state of the drug in different microspheres and their biopharmaceutical properties was found.

EPA Safer Chemical Functional Use Classes -> Surfactants|Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern|Food Additives -> ANTICAKING_AGENT; EMULSIFIER; -> JECFA Functional Classes|Cosmetics -> Anticaking; Bulking; Cosmetic colorant; Moisturising

Food Additives -> ANTICAKING_AGENT; EMULSIFIER;