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Cycrimine

Cycrimine structure

CAS No:
77-39-4
Formula:
C19H29NO
Chemical Name:
Cycrimine
Synonyms:
1-Piperidinepropanol,α-cyclopentyl-α-phenyl-;α-Cyclopentyl-α-phenyl-1-piperidinepropanol;Pagitane;1-Phenyl-1-cyclopentyl-3-piperidino-1-propanol;Cycrimine;1-Cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol;107661-05-2;87439-44-9
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

ChEBI: A member of the class of piperidines that is 3-(piperidin-1-yl)propan-1-ol in which one of the hydrogen atoms at the 1-position is substituted by cyclopentyl, and the other is substituted by phenyl. A central anticholinergic, it is used as its hydrochlorid salt in the management and treatment of Parkinson's disease.

Solid

Cycrimine is a member of the class of piperidines that is 3-(piperidin-1-yl)propan-1-ol in which one of the hydrogen atoms at the 1-position is substituted by cyclopentyl, and the other is substituted by phenyl. A central anticholinergic, it is used as its hydrochloride salt in the management and treatment of Parkinson's disease. It has a role as an antiparkinson drug, a muscarinic antagonist and an antidyskinesia agent. It is a tertiary alcohol, a member of piperidines and a tertiary amino compound.|Cycrimine is a drug used to reduce levels of acetylcholine to return a balance with dopamine in the treatment and management of Parkinson's disease.

Cycrimine Basic Attributes

Molecular Weight：

287.444

Exact Mass：

287.44

EC Number：

201-024-6

Characteristics

PSA：

23.5

XLogP3：

Appearance：

Solid

Density：

1.057g/cm3

Melting Point：

88-89 °C @ Solvent: Ethanol

Boiling Point：

125-135 °C @ Press: 0.02 Torr

Flash Point：

205.7ºC

Refractive Index：

1.554

Water Solubility：

9.09e-03 g/L

Toxicity

Protein Binding：

14-21%

Drug Information

Drug Indication：

For treatment and management of Parkinson's disease.

Pharmacology：

Cycrimine is a central anticholenergic used in the treatment of the symptoms of Parkinson's disease. It is a drug used to reduce levels of acetylcholine. Acetylcholine is usually in balance with dopamine neurotransmitters, however lower levels of dopamine are present in the brain of patients suffering from Parkinson's disease. By lowering levels of acetylcholine, it is thought that this balance may be restored.

Mechanism of Action：

Cycrimine binds the muscarinic acetylcholine receptor M1, effectively inhibiting acetylcholine. This decrease in acetylcholine restores the normal dopamine-acetylcholine balance and relieves the symptoms of Parkinson's disease.

MeSH Entry Terms：

cycrimine

Cycrimine Use and Manufacturing

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:287.4
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:287.224914549
Monoisotopic Mass:287.224914549
Topological Polar Surface Area:23.5
Heavy Atom Count:21
Complexity:301
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes