Neon

20.18

19.99240

231-110-9

4VB4Y46AHD

0627

1065|1913

DTXSID0064678

Colorless gas|Monoatomic, inert ... Does not condense at the temperature of liquid air; solid at the temperature of liquid hydrogen; the solid form exists as face-centered cubic crystals at normal pressure

0

0.28

colorless gas

0.825 g/L

-248.7 °C

-246 °C

none

H2O: negligible soluble

Keep container tightly closed in a dry and well-ventilated place. Contents under pressure.

0.7 (21 °C, vs air)

Only asphyxiating toxicity reviews

Non-flammable; non-toxic; suffocating

Exposure of the container to prolonged heat or fire may cause it to rupture violently and rocket. /Neon, compressed; Neon, refrigerated liquid/

Odorless

Tasteless

Natural neon is a mixture of three stable isotopes. Fourteen other unstable isotopes are known.|Does not form compounds, but ionizes in electric discharge tubes|Liquefies at -245.92 °C|Triple point temperature: 24.562 K, pressure 43.47 kPa|For more Other Experimental Properties (Complete) data for Neon, Elemental (8 total), please visit the HSDB record page.|LIQUID: normal BP: -246.08 °C; density: 1207 kg/cu m at 0 °C (normal bp): 1247 kg/cu m (triple point); Heat of vaporization: 1.741 kJ/mol (normal BP)

No rapid reaction with air. No rapid reaction with water.

Not Chemically Reactive

These substances undergo no chemical reactions under any known circumstances. They are nonflammable, noncombustible and nontoxic. They can asphyxiate.|These substances undergo no chemical reactions under any known circumstances. They are nonflammable, noncombustible and nontoxic. They can asphyxiate. Contact of very cold liquefied gas with water may result in vigorous or violent boiling of the product and extremely rapid vaporization due to the large temperature differences involved. If the water is hot, there is the possibility that a liquid "superheat" explosion may occur. Pressures may build to dangerous levels if liquid gas contacts water in a closed container [Handling Chemicals Safely 1980].

The gas is lighter than air.

Critical temperature: 44.40 K; critical pressure: 2654 kPa; critical density: 483 kg/cu m

2.2

UN 1065 2.2

3

38

QP4450000

Warehouse ventilated, low temperature and dry; light loading and unloading

High heat and explosive steel cylinder

Stable. Very unreactive.

P282, P315, P336, P403, P41, P403

H280

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Diagnostic Devices. A neon gas analyzer is a device intended to measure the concentration of neon in a gas mixture exhaled by a patient. The device may use techniques such as mass spectrometry or thermal conductivity.

Excerpt from ERG Guide 121 [Gases - Inert]: Non-flammable gases. Containers may explode when heated. Ruptured cylinders may rocket. (ERG, 2016)|Excerpt from ERG Guide 120 [Gases - Inert (Including Refrigerated Liquids)]: Non-flammable gases. Containers may explode when heated. Ruptured cylinders may rocket. (ERG, 2016)|Not combustible. Heating will cause rise in pressure with risk of bursting.

|Warning|H280 (62.21%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]|P282, P315, P336, P403, and P410+P403|Aggregated GHS information provided by 426 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Excerpt from ERG Guide 121 [Gases - Inert]: As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 100 meters (330 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)|Excerpt from ERG Guide 120 [Gases - Inert (Including Refrigerated Liquids)]: As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 100 meters (330 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 121 [Gases - Inert]: Do not touch or walk through spilled material. Stop leak if you can do it without risk. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Do not direct water at spill or source of leak. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Allow substance to evaporate. Ventilate the area. (ERG, 2016)|Excerpt from ERG Guide 120 [Gases - Inert (Including Refrigerated Liquids)]: Do not touch or walk through spilled material. Stop leak if you can do it without risk. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Do not direct water at spill or source of leak. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Allow substance to evaporate. Ventilate the area. CAUTION: When in contact with refrigerated/cryogenic liquids, many materials become brittle and are likely to break without warning. (ERG, 2016)

Excerpt from ERG Guide 121 [Gases - Inert]: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. (ERG, 2016)|Excerpt from ERG Guide 120 [Gases - Inert (Including Refrigerated Liquids)]: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. Always wear thermal protective clothing when handling refrigerated/cryogenic liquids or solids. (ERG, 2016)|Personnel protection: Wear appropriate chemical protective gloves, boots, and goggles. /Neon, compressed; Neon, refrigerated liquid/|Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).|Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Exposure of the container to prolonged heat or fire may cause it to rupture violently and rocket. /Neon, compressed; Neon, refrigerated liquid/

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. /Neon, compressed; Neon, refrigerated liquid/|Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective equipment for fire-fighters: Wear self contained breathing apparatus for fire fighting if necessary.

Personal precautions: Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Clean up promptly by sweeping or vacuum.

If material not involved in fire: Attempt to stop leak it without undue personnel hazard. /Neon, compressed; Neon, refrigerated liquid/|Personnel protection: Avoid breathing vapors. Keep upwind. Do not handle broken packages unless wearing appropriate personal protective equipment. /Neon, compressed; Neon, refrigerated liquid/|Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.|Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

/GUIDE 120: GASES - INERT (INCLUDING REFRIGERATED LIQUIDS)/ Health: Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. /Neon, refrigerated liquid (cryogenic liquid)/|/GUIDE 120: GASES - INERT (INCLUDING REFRIGERATED LIQUIDS)/ Fire or Explosion: Non-flammable gases. Containers may explode when heated. Ruptured cylinders may rocket. /Neon, refrigerated liquid (cryogenic liquid)/|/GUIDE 120: GASES - INERT (INCLUDING REFRIGERATED LIQUIDS)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. Ventilate closed spaces before entering. /Neon, refrigerated liquid (cryogenic liquid)/|/GUIDE 120: GASES - INERT (INCLUDING REFRIGERATED LIQUIDS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. Always wear thermal protective clothing when handling refrigerated/cryogenic liquids or solids. /Neon, refrigerated liquid (cryogenic liquid)/|For more DOT Emergency Guidelines (Complete) data for Neon, Elemental (16 total), please visit the HSDB record page.

Personal protection: self-contained breathing apparatus. Ventilation.

Fireproof if in building. Keep in a well-ventilated room.

On loss of containment this substance can cause suffocation by lowering the oxygen content of the air in confined areas.

Asphyxiation.

Use ventilation.

In high concentrations, neon gas may act as a simple asphyxiant by displacing oxygen from the atmosphere leading to decreased alveolar partial oxygen pressure and hypoxemia.

...The anesthetic properties of helium and neon at hyperbaric pressures /were assessed/ by testing their capacity to decrease anesthetic requirement for desflurane using electrical stimulation of the tail as the anesthetic endpoint (ie, the minimum alveolar anesthetic concentration [MAC]) in rats. Partial pressures of helium or neon near those predicted to produce anesthesia by the Meyer-Overton hypothesis (approximately 80-90 atm), tended to increase desflurane MAC, and these partial pressures of helium and neon produced convulsions when administered alone. ... It has been thought that the high pressures of helium and neon that might be needed to produce anesthesia, antagonize their anesthetic properties (pressure reversal of anesthesia). /The authors/ propose an alternative explanation: like other compounds with a low affinity to water, helium and neon are intrinsically without anesthetic effect.

No pharmacokinetic data available.

Neon is a rare gaseous element present in the atmosphere to the extent of 1 part in 65,000 parts of air.

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,416 workers (125 of these were female) were potentially exposed to neon in the US(1).

Indicated for use as a diagnostic tracer gas in pulmonary function tests.

/Experimental Therapy/ Thirty-nine patients with primary or recurrent glioma of the brain were irradiated wholely or in part with heavy charged particle beams ... in a Phase I-II clinical trial ... . During the course of this trial, treatment techniques have been developed and tumor doses have been escalated in order to obtain data on normal brain toxicity and response of malignant glioma of the brain. Toxicity has been acceptable with a low level of brain injury. Survival and tumor control has been approximately the same as historical results in glioma of the brain. Further dose escalation is planned together with possible trial of combined modality therapy.|/Experimental Therapy/ Neon ion radiotherapy possesses biologic and physical advantages over megavoltage X rays. Biologically, the neon beam reduces the oxygen enhancement ratio and increases relative biological effectiveness. Cells irradiated by neon ions show less variation in cell-cycle related radiosensitivity and decreased repair of radiation injury. The physical behavior of heavy charged particles allows precise delivery of high radiation doses to tumors while minimizing irradiation of normal tissues. In 1979 a Phase I-II clinical trial was started at Lawrence Berkeley Laboratory using neon ions to irradiate patients for whom conventional treatment modalities were ineffective. By the end of 1988 a total of 239 patients had received a minimum neon physical dose of 1000 cGy (median follow-up for survivors 32 months). Compared with historical results, the 5-year actuarial disease-specific survival (DSS5) and local control (LC5) rates suggest that neon treatment improves outcome for several types of tumors: a) advanced or recurrent macroscopic salivary gland carcinomas (DSS5 59%; LC5 61%); b) paranasal sinus tumors (DSS5 69%; LC5 69% for macroscopic disease); c) advanced soft tissue sarcomas (DSS5 56%, LC5 56% for macroscopic disease); d) macroscopic sarcomas of bone (DSS5 45%; LC5 59%); e) locally advanced prostate carcinomas (DSS5 90%; LC5 75%); and f) biliary tract carcinomas (DSS5 28%; LC5 44%). Treatment of malignant gliomas, pancreatic, gastric, esophageal, lung, and advanced or recurrent head and neck cancer has been less successful; results for these tumors appear no better than those achieved with conventional x-ray therapy...

A study demonstrated that neon beam radiotherapy improved the 5-year actuarial disease-specific survival rate and local control in patients with paranasal sinus tumours, macroscopic salivary gland tumours, bile duct carcinomas, macroscopic soft tissue and bone sarcomas, and advanced prostate carcinomas.

No pharmacokinetic data available.

No pharmacokinetic data available.

No pharmacokinetic data available.

In a pulmonary diffusion capacity test, the diffusing capacity for carbon monoxide (Dlco) assesses the rate at which oxygen is transferred from the lung to the pulmonary capillary bed. In a neon gas analyzer, the mixture of carbon monoxide, neon gas, oxygen, and the balance nitrogen is inhaled by the individual and is eventually exhaled after being held at near full inspiration for brief seconds. The concentrations and ratio of carbon monoxide and neon is measured in the alveolar fraction of the expired gas. The change in the concentration of the tracer gas reflects the mean alveolar carbon monoxide concentration at the start of the breath hold and provides a measure of alveolar volume by gas dilution. Neon ion radiotherapy has high linear energy transfer thus produces biological behaviour similar to neutron beams. The rays are associated with a reduction in the oxygen enhancement ratio, which allows for more specificity for hypoxic cells, less variation in cell-cycle related radio sensitivity, and less capability for repair of radiation injury.

Excerpt from ERG Guide 121 [Gases - Inert]: Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. (ERG, 2016)|Excerpt from ERG Guide 120 [Gases - Inert (Including Refrigerated Liquids)]: Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. (ERG, 2016)

Excerpt from ERG Guide 121 [Gases - Inert]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Keep victim calm and warm. (ERG, 2016)|Excerpt from ERG Guide 120 [Gases - Inert (Including Refrigerated Liquids)]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Clothing frozen to the skin should be thawed before being removed. In case of contact with liquefied gas, thaw frosted parts with lukewarm water. Keep victim calm and warm. (ERG, 2016)

Fresh air, rest. Artificial respiration may be needed. Seek medical attention if you feel unwell.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Simple asphyxiants and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Anticipate seizures and treat if necessary ... . Use rapid rewarming techniques if frostbite occurs ... . /Simple asphyxiants and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or is in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Treat seizures with diazepam or lorazepam ... . /Simple asphyxiants and related compounds/

/SIGNS AND SYMPTOMS/ Contact with the liquid can cause frostbite. /Neon, refrigerated liquid/|/OTHER TOXICITY INFORMATION/ Neon is among the number of gases and vapors that, when present in high concentrations in air, act primarily as simple asphyxiants without other significant physiologic effects.

Neon

Dizziness. Lethargy. Headache. Suffocation.

Grade: Technical, highest purity

Neon: ACTIVE

Diagnostic Devices. A neon gas analyzer is a device intended to measure the concentration of neon in a gas mixture exhaled by a patient. The device may use techniques such as mass spectrometry or thermal conductivity.